Acute Leukemias: Molecular Characterization, Leukemia-Initiating Cells, and Influence of the Microenvironment

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Editorial

10 May 2023

Editorial: Acute leukemias: molecular characterization, leukemia-initiating cells, and influence of the microenvironment

Garrett M. Dancik

,

Lokman Varisli

,

Ioannis F. Voutsas

and

Spiros Vlahopoulos

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Editors

4

Spiros Vlahopoulos

First Pediatric Clinic, University of Athens

Eastern Connecticut State University

IOANNIS VOUTSAS

Hospital Agios Savvas

Department of Molecular Biology and Genetic, Faculty of Science, Dicle University

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Molecular characterization of acute leukemias remains an important challenge as a significant part of the cases cannot be cured. The molecular mechanisms of disease progression and the pathways to recurrent disease will require years of research until our comprehension enables the development of simple and effective cures.

The concept of Leukemia-Initiating Cells, or Leukemia Stem Cells enables us to model disease progression and resistance to treatment. An important component that mediates the impact of leukemia on the host is the interaction between malignant cells and the tissue microenvironment. Addressing these critical factors is imperative in the pursuit of knowledge that will enable progress in the development of diagnostic tools, prognostic methodology, and effective treatment.

We welcome manuscripts that address the characterization of the molecular underpinning of acute leukemias. Work that addresses the contribution of leukemia stem cells is especially important. Furthermore, research on the influence of the microenvironment is expected to contribute critical progress to the field. In this direction, studies of cellular transitions and interactions that affect immunity, inflammation & homeostasis, can help develop methods to use host factors to control the disease. Work that examines the prognostic value of cellular and molecular factors is also invited.

Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.

Molecular characterization of acute leukemias remains an important challenge as a significant part of the cases cannot be cured. The molecular mechanisms of disease progression and the pathways to recurrent disease will require years of research until our comprehension enables the development of simple and effective cures.

The concept of Leukemia-Initiating Cells, or Leukemia Stem Cells enables us to model disease progression and resistance to treatment. An important component that mediates the impact of leukemia on the host is the interaction between malignant cells and the tissue microenvironment. Addressing these critical factors is imperative in the pursuit of knowledge that will enable progress in the development of diagnostic tools, prognostic methodology, and effective treatment.

We welcome manuscripts that address the characterization of the molecular underpinning of acute leukemias. Work that addresses the contribution of leukemia stem cells is especially important. Furthermore, research on the influence of the microenvironment is expected to contribute critical progress to the field. In this direction, studies of cellular transitions and interactions that affect immunity, inflammation & homeostasis, can help develop methods to use host factors to control the disease. Work that examines the prognostic value of cellular and molecular factors is also invited.

Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.

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Editors

Spiros Vlahopoulos

First Pediatric Clinic, University of Athens

Eastern Connecticut State University

IOANNIS VOUTSAS

Hospital Agios Savvas

Department of Molecular Biology and Genetic, Faculty of Science, Dicle University

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Frontiers in Oncology

Hematologic Malignancies

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