T helper cells (Th) are a type of white blood cells expressing CD4 on their surface, including Th1, Th2, Th9, Th17, Th22, follicular helper T (Tfh) cells, and regulatory T (Treg) cells. T helper cells are activated when they interact with antigen-presenting cells, such as dendritic cells. Their differentiation is driven by cytokines and specific types of antigens. T helper cells secret cytokines to communicate with other immune cells, including B cells, cytotoxic T lymphocytes and phagocytes. T helper cells play a central role in immune response regulation, immune cell homeostasis maintenance, and immunopathology prevention. They are essential in the activation and growth of cytotoxic T cells, B cell antibody class switching, maximizing bactericidal activity of phagocytes, and they are also important for the immune system to give proper responses to different types of immunological insults. On the other hand, the imbalance of T helper cells’ differentiation and the subsequent cytokine dysregulation are implicated in autoimmune diseases, inflammation, and tumors. The immune balance is regulated by many factors such as the environment, stress, and aging. It is urgent to find the corresponding key regulators and regulating pathways. The goal of this Research Topic is to provide a forum focusing on the T helper cells’ differentiation, polarization, and their potential as therapeutic targets for inflammatory diseases.
We welcome submissions of Original Research, Perspective, Clinical Trial, Case Report, Review, Mini Review and Opinion articles on human and/or animal studies that cover, but are not limited to, the following topics:
1. Regulation of T helper cells’ differentiation
2. The interaction between T helper cells and other immune cells including B cells, cytotoxic T lymphocytes, phagocytes, and innate lymphoid cells
3. Role of T helper cells in the pathological mechanism of autoimmune diseases, infectious diseases, inflammation, or tumors, such as rheumatoid arthritis, psoriasis, multiple sclerosis, asthma, systemic lupus erythematosus, inflammatory bowel disease, different cancers, etc
4. Use of T helper cells or related cytokines and signaling pathways as a therapeutic target
5. Role of T helper cells in COVID-19 and the vaccine
T helper cells (Th) are a type of white blood cells expressing CD4 on their surface, including Th1, Th2, Th9, Th17, Th22, follicular helper T (Tfh) cells, and regulatory T (Treg) cells. T helper cells are activated when they interact with antigen-presenting cells, such as dendritic cells. Their differentiation is driven by cytokines and specific types of antigens. T helper cells secret cytokines to communicate with other immune cells, including B cells, cytotoxic T lymphocytes and phagocytes. T helper cells play a central role in immune response regulation, immune cell homeostasis maintenance, and immunopathology prevention. They are essential in the activation and growth of cytotoxic T cells, B cell antibody class switching, maximizing bactericidal activity of phagocytes, and they are also important for the immune system to give proper responses to different types of immunological insults. On the other hand, the imbalance of T helper cells’ differentiation and the subsequent cytokine dysregulation are implicated in autoimmune diseases, inflammation, and tumors. The immune balance is regulated by many factors such as the environment, stress, and aging. It is urgent to find the corresponding key regulators and regulating pathways. The goal of this Research Topic is to provide a forum focusing on the T helper cells’ differentiation, polarization, and their potential as therapeutic targets for inflammatory diseases.
We welcome submissions of Original Research, Perspective, Clinical Trial, Case Report, Review, Mini Review and Opinion articles on human and/or animal studies that cover, but are not limited to, the following topics:
1. Regulation of T helper cells’ differentiation
2. The interaction between T helper cells and other immune cells including B cells, cytotoxic T lymphocytes, phagocytes, and innate lymphoid cells
3. Role of T helper cells in the pathological mechanism of autoimmune diseases, infectious diseases, inflammation, or tumors, such as rheumatoid arthritis, psoriasis, multiple sclerosis, asthma, systemic lupus erythematosus, inflammatory bowel disease, different cancers, etc
4. Use of T helper cells or related cytokines and signaling pathways as a therapeutic target
5. Role of T helper cells in COVID-19 and the vaccine