Virus-induced disease contributes to significant detrimental impacts on global health and the economy. Innate immunity represents the first barrier against viral infection, where innate host-defense mechanisms can vary dramatically depending on the type of virus encountered, the concerned tissue, and the type of infection elicited (acute vs chronic). Indeed, infection of different cell types by different viruses induces a broad spectrum of innate antiviral host responses, which act to limit severe disease and help orchestrate effective adaptive immune responses to clear infection. Viruses have also evolved to use diverse strategies to hijack the cellular machinery to benefit replication and effectively circumvent innate host-defense mechanisms. Despite the breadth and complexity of host immune responses directed towards distinct virus families, similarities exist and important lessons can be learnt by examining and comparing innate antiviral responses elicited during diverse viral infections. Deciphering the mechanisms utilized by viruses to escape innate immunity would also help identify key cellular factors and develop broad-spectrum host-targeted antiviral strategies.
We aim to bring together research focusing on the present state of key findings in innate antiviral immunity directed towards different viruses. More particularly we are interested in studies of SARS-CoV2 virus, influenza viruses and hepatitis viruses. Understanding how viruses are controlled by or escape host innate immunity and how the antiviral response develops during infection is of primary interest. Similarities exist and important lessons can be learnt by examining and comparing innate antiviral responses elicited during diverse viral infections. The more we learn from the relationship between viruses and effective innate host immunity, the better we are positioned to develop effective and novel strategies to broadly prevent infection or treat severe disease.
We welcome the submission of Original Research, Systematic Review, Methods, Review, Mini Review, Hypothesis and Theory, and Perspective articles around the following topics:
- The role of innate antiviral immunity against SARS-CoV2 virus and influenza viruses (acute infection) and hepatitis viruses (chronic infection).
- Viral sensing by different families of pattern recognition receptors, interferon signaling and induction of interferon responses, activation, cytosolic immunity, inflammation in different cell types, not restricted to innate immune cell subsets (ie: macrophages, dendritic cells, natural killer cells, neutrophils).
- Viral escape of innate immunity, and mechanisms underpinning circumventing host responses, including metabolic alterations that can skew the innate antiviral immune response
- We welcome in vitro and in vivo studies.
Virus-induced disease contributes to significant detrimental impacts on global health and the economy. Innate immunity represents the first barrier against viral infection, where innate host-defense mechanisms can vary dramatically depending on the type of virus encountered, the concerned tissue, and the type of infection elicited (acute vs chronic). Indeed, infection of different cell types by different viruses induces a broad spectrum of innate antiviral host responses, which act to limit severe disease and help orchestrate effective adaptive immune responses to clear infection. Viruses have also evolved to use diverse strategies to hijack the cellular machinery to benefit replication and effectively circumvent innate host-defense mechanisms. Despite the breadth and complexity of host immune responses directed towards distinct virus families, similarities exist and important lessons can be learnt by examining and comparing innate antiviral responses elicited during diverse viral infections. Deciphering the mechanisms utilized by viruses to escape innate immunity would also help identify key cellular factors and develop broad-spectrum host-targeted antiviral strategies.
We aim to bring together research focusing on the present state of key findings in innate antiviral immunity directed towards different viruses. More particularly we are interested in studies of SARS-CoV2 virus, influenza viruses and hepatitis viruses. Understanding how viruses are controlled by or escape host innate immunity and how the antiviral response develops during infection is of primary interest. Similarities exist and important lessons can be learnt by examining and comparing innate antiviral responses elicited during diverse viral infections. The more we learn from the relationship between viruses and effective innate host immunity, the better we are positioned to develop effective and novel strategies to broadly prevent infection or treat severe disease.
We welcome the submission of Original Research, Systematic Review, Methods, Review, Mini Review, Hypothesis and Theory, and Perspective articles around the following topics:
- The role of innate antiviral immunity against SARS-CoV2 virus and influenza viruses (acute infection) and hepatitis viruses (chronic infection).
- Viral sensing by different families of pattern recognition receptors, interferon signaling and induction of interferon responses, activation, cytosolic immunity, inflammation in different cell types, not restricted to innate immune cell subsets (ie: macrophages, dendritic cells, natural killer cells, neutrophils).
- Viral escape of innate immunity, and mechanisms underpinning circumventing host responses, including metabolic alterations that can skew the innate antiviral immune response
- We welcome in vitro and in vivo studies.
