Oxygen (O2) is a vital nutrient for aerobic organisms, as it is used to produce energy necessary for a number of cellular processes. Being oxygen homeostasis crucial to maintain survival, mammals have developed finely regulated mechanisms in response to oxygen variations. However, these mechanisms may fail to keep adequate intracellular oxygen level and when the concentration of oxygen decreases below a certain threshold, a condition called “hypoxia” takes place, which in turn causes cellular stress. Under hypoxic conditions, cells activate adaptive responses through signaling pathways that involve transcriptional regulation. Key regulators of hypoxic response are hypoxia inducible factors (HIFs), transcription factors that react to decreases level of oxygen available in the cell and regulate gene expression. It has been shown that hypoxia can induce inflammation and that, conversely, inflammation can lead to hypoxia. In addition, hypoxia can influence immune cell response regulating metabolic pathways and can be a pathogenic factor for some inflammatory diseases.
In this Research Topic we aim at gathering articles discussing the two-way relationship between hypoxia and inflammation as well as the impact on immune cells function and on pathogenesis of inflammatory diseases.
We particularly welcome submission of Original Research, Review, Mini Review, and Perspective articles on the following sub-topics:
• Molecular pathways regulating response to hypoxia
• Mediators of hypoxic response
• Adaptive and maladaptive hypoxia-induced inflammation
• Inflammatory phenotypes induced by hypoxia
• Impact of chronic hypoxia on the immune function
• Hypoxia in sterile and non-sterile immunity
• Inflammatory conditions leading to hypoxia
Topic Editor Prof. Philippe Saas is the shareholder of Med’Inn’Pharma, related to the development of anti-inflammatory treatment. At this stage, the mechanisms of action of this treatment has no link with hypoxia. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Oxygen (O2) is a vital nutrient for aerobic organisms, as it is used to produce energy necessary for a number of cellular processes. Being oxygen homeostasis crucial to maintain survival, mammals have developed finely regulated mechanisms in response to oxygen variations. However, these mechanisms may fail to keep adequate intracellular oxygen level and when the concentration of oxygen decreases below a certain threshold, a condition called “hypoxia” takes place, which in turn causes cellular stress. Under hypoxic conditions, cells activate adaptive responses through signaling pathways that involve transcriptional regulation. Key regulators of hypoxic response are hypoxia inducible factors (HIFs), transcription factors that react to decreases level of oxygen available in the cell and regulate gene expression. It has been shown that hypoxia can induce inflammation and that, conversely, inflammation can lead to hypoxia. In addition, hypoxia can influence immune cell response regulating metabolic pathways and can be a pathogenic factor for some inflammatory diseases.
In this Research Topic we aim at gathering articles discussing the two-way relationship between hypoxia and inflammation as well as the impact on immune cells function and on pathogenesis of inflammatory diseases.
We particularly welcome submission of Original Research, Review, Mini Review, and Perspective articles on the following sub-topics:
• Molecular pathways regulating response to hypoxia
• Mediators of hypoxic response
• Adaptive and maladaptive hypoxia-induced inflammation
• Inflammatory phenotypes induced by hypoxia
• Impact of chronic hypoxia on the immune function
• Hypoxia in sterile and non-sterile immunity
• Inflammatory conditions leading to hypoxia
Topic Editor Prof. Philippe Saas is the shareholder of Med’Inn’Pharma, related to the development of anti-inflammatory treatment. At this stage, the mechanisms of action of this treatment has no link with hypoxia. The other Topic Editors declare no competing interests with regard to the Research Topic subject.