About this Research Topic
It is well-established that obesity is a state of low-grade inflammation, with expanded adipose tissue infiltrated by immune cells and producing high levels of inflammatory mediators. However, the impact of obesity on the outcome of "classical" inflammatory conditions remains somewhat controversial. This topic is centered around mechanisms by which obesity alters the risk and natural history of acute and chronic inflammatory pathologies, including infectious diseases, critical illness and trauma, acute and chronic pancreatitis, inflammatory bowel disease, rheumatoid arthritis, allergic and autoimmune conditions and more. Basic, clinical and epidemiological studies as well as review articles addressing the pathogenetic mechanisms of the connection between obesity and inflammatory disease and/or the effect of obesity on disease outcome are welcome.
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