Epidemiological data show that COVID-19 is able to produce long term symptoms, producing a new disease named chronic COVID-19. Long COVID19 is the syndrome characterised by the perdurance of symptoms present at start that were suggestive of COVID-19 and not recovering for several weeks, whether you were tested or not. Many symptoms and syndromes associated with chronic COVID-19 have been described, including anxiety, depression, kidney insufficiency, diabetes mellitus, cardiovascular diseases, chronic fatigue, thromboembolism, hair loss and COVID-19 induced small intestinal bacterial overgrowth syndrome. Sub-acute and chronic COVID-19 affects in between 20-87% of acute COVID-19 patients, suffering mostly from fatigue (53.1%), dyspnea (43.4%), joint pain (27.3%) and chest pain (21.7%). Chronic COVID-19 is further responsible for long term work absence producing a severe burden not only on the patients health but also at the social and economical level.
Our goal is to engage scientists and clinician to publish papers about the mechanisms leading to chronic COVID-19, treatment options, epidemiology, risk factors and new hypothesis. The development of chronic COVID-19 seems to be related with three central mechanisms, e.q. severe oxidative pressure, chronic hypoxia and long lasting immune dsiturbances. Possible explanations for these mechanisms are viral persistance, residual viral load, immunological disturbances, epigenetic mutations, tissue and organ damage and iatrogenic factors. Organs affected by chronic COVID-19 are vital for survival and the way SARS-COV-2 infilltrates in these organs at distance of the main entrance organ (the nasopharyngeal space) needs to be explained. Possible cell types infected by SARS-COV-2 are erytrocytes, thrombocytes and adipocytes and they could be used as Trojan horses for virus spread and perhaps even intracellular persistance in these and possibly other migrating cell types such as T lymphocytes. To find proximate solutions we need ultimate explanations. Where does this virus comes from? How did it develop these strategies to proliferate? Why are we losing the evolutionary struggle?
The scope of our Research Topic is to clarify the possible long term impact of the COVID-19 pandemic at the level of treatment options, prognosis, pathophysiological mechanisms, preventive measurements, clinical manifestations and diagnosis. Clarifying what makes induviduals susceptible for chronic COVID-19 opens up for the development of primary and secondary preventive interventions. Not only human research is indicated, but also representative animal studies are welcome. Special interest will be given to manuscripts related with psychological and psychiatrical factors of COVID-19 and based not only on proximate mechanisms but also ultimate reasoning.
Epidemiological data show that COVID-19 is able to produce long term symptoms, producing a new disease named chronic COVID-19. Long COVID19 is the syndrome characterised by the perdurance of symptoms present at start that were suggestive of COVID-19 and not recovering for several weeks, whether you were tested or not. Many symptoms and syndromes associated with chronic COVID-19 have been described, including anxiety, depression, kidney insufficiency, diabetes mellitus, cardiovascular diseases, chronic fatigue, thromboembolism, hair loss and COVID-19 induced small intestinal bacterial overgrowth syndrome. Sub-acute and chronic COVID-19 affects in between 20-87% of acute COVID-19 patients, suffering mostly from fatigue (53.1%), dyspnea (43.4%), joint pain (27.3%) and chest pain (21.7%). Chronic COVID-19 is further responsible for long term work absence producing a severe burden not only on the patients health but also at the social and economical level.
Our goal is to engage scientists and clinician to publish papers about the mechanisms leading to chronic COVID-19, treatment options, epidemiology, risk factors and new hypothesis. The development of chronic COVID-19 seems to be related with three central mechanisms, e.q. severe oxidative pressure, chronic hypoxia and long lasting immune dsiturbances. Possible explanations for these mechanisms are viral persistance, residual viral load, immunological disturbances, epigenetic mutations, tissue and organ damage and iatrogenic factors. Organs affected by chronic COVID-19 are vital for survival and the way SARS-COV-2 infilltrates in these organs at distance of the main entrance organ (the nasopharyngeal space) needs to be explained. Possible cell types infected by SARS-COV-2 are erytrocytes, thrombocytes and adipocytes and they could be used as Trojan horses for virus spread and perhaps even intracellular persistance in these and possibly other migrating cell types such as T lymphocytes. To find proximate solutions we need ultimate explanations. Where does this virus comes from? How did it develop these strategies to proliferate? Why are we losing the evolutionary struggle?
The scope of our Research Topic is to clarify the possible long term impact of the COVID-19 pandemic at the level of treatment options, prognosis, pathophysiological mechanisms, preventive measurements, clinical manifestations and diagnosis. Clarifying what makes induviduals susceptible for chronic COVID-19 opens up for the development of primary and secondary preventive interventions. Not only human research is indicated, but also representative animal studies are welcome. Special interest will be given to manuscripts related with psychological and psychiatrical factors of COVID-19 and based not only on proximate mechanisms but also ultimate reasoning.
