The gastrointestinal tract consists of different organs, and due to the variety of organs encompassed in this term, there are many diseases defined within this organ system. Despite the wide variety of research and advances in the field of gastroenterology, more research is still needed to treat and improve our understanding of these related disorders. Diseases such as inflammatory bowel disease (IBD) which, despite anti-TNF-based therapies, still require the development of new therapies to better address the complexity of the disease. Liver fibrosis is also one of the chronic diseases for which no effective treatment has been found. We also see the increasing impact of lifestyle changes and a growing number of fatty liver diseases, so there is a need to develop treatment (and preventative) methods in this area. Gastrointestinal cancers are also another very important part of the disease spectrum; Colorectal cancer, stomach cancer and pancreatic cancer are among the most common cancers with a high mortality rate worldwide.
Cell and gene therapy presented us with new approaches and solutions for the treatment of incurable/difficult/complex gastrointestinal diseases. Cell therapies utilizing mesenchymal stem cells are proving effective to treat IBD patients, including complex Crohn's fistula diseases. In addition, the use of regulatory T cells and dendritic cells (DC) has also delivered promising results. In the case of liver fibrosis, the use of macrophages has improved symptoms and reversed the disease pathology. There have also been many trials in the treatment of gastrointestinal cancers using natural killer (NK), T-cell and DC cells, all of which have given us more hope of finding definitive cures for incurable gastrointestinal diseases. Extensive research has been done recently on the secretome and exosomes in the treatment of gastrointestinal diseases, which shows that these particles have therapeutic potential as carriers or independently.
Our goal in this research topic is to collect the latest findings and achievements in the field of cell therapy in gastrointestinal and liver diseases.
We welcome submissions of Original research, Review and Mini-Review articles in the following topics:
- Stem cell therapy in gastrointestinal and liver diseases
- Immune cell therapy in gastrointestinal and liver diseases
- Gene therapy in gastrointestinal and liver diseases
- Extracellular vesicles in gastrointestinal and liver diseases
-Cancer stem cells and EMT in gastrointestinal and liver diseases
The gastrointestinal tract consists of different organs, and due to the variety of organs encompassed in this term, there are many diseases defined within this organ system. Despite the wide variety of research and advances in the field of gastroenterology, more research is still needed to treat and improve our understanding of these related disorders. Diseases such as inflammatory bowel disease (IBD) which, despite anti-TNF-based therapies, still require the development of new therapies to better address the complexity of the disease. Liver fibrosis is also one of the chronic diseases for which no effective treatment has been found. We also see the increasing impact of lifestyle changes and a growing number of fatty liver diseases, so there is a need to develop treatment (and preventative) methods in this area. Gastrointestinal cancers are also another very important part of the disease spectrum; Colorectal cancer, stomach cancer and pancreatic cancer are among the most common cancers with a high mortality rate worldwide.
Cell and gene therapy presented us with new approaches and solutions for the treatment of incurable/difficult/complex gastrointestinal diseases. Cell therapies utilizing mesenchymal stem cells are proving effective to treat IBD patients, including complex Crohn's fistula diseases. In addition, the use of regulatory T cells and dendritic cells (DC) has also delivered promising results. In the case of liver fibrosis, the use of macrophages has improved symptoms and reversed the disease pathology. There have also been many trials in the treatment of gastrointestinal cancers using natural killer (NK), T-cell and DC cells, all of which have given us more hope of finding definitive cures for incurable gastrointestinal diseases. Extensive research has been done recently on the secretome and exosomes in the treatment of gastrointestinal diseases, which shows that these particles have therapeutic potential as carriers or independently.
Our goal in this research topic is to collect the latest findings and achievements in the field of cell therapy in gastrointestinal and liver diseases.
We welcome submissions of Original research, Review and Mini-Review articles in the following topics:
- Stem cell therapy in gastrointestinal and liver diseases
- Immune cell therapy in gastrointestinal and liver diseases
- Gene therapy in gastrointestinal and liver diseases
- Extracellular vesicles in gastrointestinal and liver diseases
-Cancer stem cells and EMT in gastrointestinal and liver diseases