Immunocellular Mechanisms and Endocrine Organs

The homeostatic and immunoregulatory functions of innate immune cells that reside within various endocrine organs have recently come to the fore. It is becoming increasingly clear that these innate cells, which include NK cells, dendritic cells, macrophages, mast cells as well as neutrophils, are not only first responders to pathogens but also can serve to support function in various tissue niches. There are also considerable research efforts aimed at uncovering the roles of such innate immune cells in pathogenesis of endocrine-related disorders such as, but not limited to, Addison’s Disease, Diabetes Mellitus/ Insipidus and pituitary insufficiencies.
This Research Topic is dedicated to appraising current knowledge on how these innate immune cells contribute to function and regulation of various endocrine organs in healthy as well as the various spectrums of diseased states. With emphasis on autocrine, paracrine as well as inter-organ signalling pathways, experts will weigh in on the latest findings with an overarching goal of consolidating innate immune cell contribution and cytokine landscapes across different endocrine loops.
We welcome original research, reviews, mini reviews, and perspective articles relating to the following subjects that do not encompass autoimmunity:

• Innate immune cells and regulation within the thyroid gland, pancreatic islets, pituitary gland, adrenal gland (particularly the adrenal cortex) and visceral fat depots.
• Autocrine and paracrine modes of communication between innate immune cell and various types of endocrine cells with impact on hormone secretion.
• The role of innate immune cells in the pathogenesis of endocrine disorders
• Emerging therapies targeting innate immune cells for endocrine disorders