Liver cancer is one of the most common cancers and a leading cause of cancer-related deaths worldwide. Hepatocellular carcinoma (HCC) is the most common form of liver cancer and is the fifth leading cancer globally. Liver cancer has a high mortality rate, low survival rate and poor prognosis primarily due to the challenges with early detection. Approximately over 60% of patients are diagnosed in the advanced stages of the disease and not able to undertake curative treatments including resection and percutaneous ablation. Therefore, further studies are required to identify potential curative therapeutic strategies and treatment for liver cancer patients.
Stereotactic body radiotherapy (SBRT) is a current form of curative treatment for primary and metastatic liver tumors and is feasible for patients who are inoperable or who are undergoing systemic therapy. There are various methods were SBRT can be performed, these include 3D conformal radiotherapy (3DCRT), intensity modulated radiotherapy (IMRT), dynamic conformal arc therapy (DCAT), volumetric-modulated arc therapy (VMAT), Tomotherapy, and CyberKnife. Studies have been performed to identify the most efficient method of SBRT to improve the prognosis for liver cancer. Magnetic resonance (MR) guided SBRT has been found to have potential of improving the quality of treatment and allowing for higher tumoricidal irradiation doses whilst simultaneously avoiding damage to organs which may be at risk. However, further studies are required regarding the treatment outcome.
Radiofrequency ablation (RFA) is also considered a favorable option for patients as it is minimally invasive compared to surgical resection. However, studies have identified RFA as a potentially controversial method of treatment in colorectal liver metastasis (CRLM) patients. There are also current studies identifying the influence of radiotherapy on liver cancer recurrence to understand how to prevent and treat radiation-induced liver damage. Currently, the clinical factors which influence liver regeneration after radiotherapy require further studies to be understood.
The goal of this Research Topic is to inspire a discussion around the influence of radiation therapies have on liver cancer patients and how the impact the mortality, prognosis and survival rate. We welcome Original Research, Reviews, Systematic Reviews and Mini-Reviews. Topics of interest include:
-Palliative Radiotherapy on Liver Cancer
-Stereotactic Body Radiotherapy (SBRT)
-Magnetic Resonance Guided SBRT
-Radiofrequency Ablation
-Radiotherapy and Liver Recurrence
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Liver cancer is one of the most common cancers and a leading cause of cancer-related deaths worldwide. Hepatocellular carcinoma (HCC) is the most common form of liver cancer and is the fifth leading cancer globally. Liver cancer has a high mortality rate, low survival rate and poor prognosis primarily due to the challenges with early detection. Approximately over 60% of patients are diagnosed in the advanced stages of the disease and not able to undertake curative treatments including resection and percutaneous ablation. Therefore, further studies are required to identify potential curative therapeutic strategies and treatment for liver cancer patients.
Stereotactic body radiotherapy (SBRT) is a current form of curative treatment for primary and metastatic liver tumors and is feasible for patients who are inoperable or who are undergoing systemic therapy. There are various methods were SBRT can be performed, these include 3D conformal radiotherapy (3DCRT), intensity modulated radiotherapy (IMRT), dynamic conformal arc therapy (DCAT), volumetric-modulated arc therapy (VMAT), Tomotherapy, and CyberKnife. Studies have been performed to identify the most efficient method of SBRT to improve the prognosis for liver cancer. Magnetic resonance (MR) guided SBRT has been found to have potential of improving the quality of treatment and allowing for higher tumoricidal irradiation doses whilst simultaneously avoiding damage to organs which may be at risk. However, further studies are required regarding the treatment outcome.
Radiofrequency ablation (RFA) is also considered a favorable option for patients as it is minimally invasive compared to surgical resection. However, studies have identified RFA as a potentially controversial method of treatment in colorectal liver metastasis (CRLM) patients. There are also current studies identifying the influence of radiotherapy on liver cancer recurrence to understand how to prevent and treat radiation-induced liver damage. Currently, the clinical factors which influence liver regeneration after radiotherapy require further studies to be understood.
The goal of this Research Topic is to inspire a discussion around the influence of radiation therapies have on liver cancer patients and how the impact the mortality, prognosis and survival rate. We welcome Original Research, Reviews, Systematic Reviews and Mini-Reviews. Topics of interest include:
-Palliative Radiotherapy on Liver Cancer
-Stereotactic Body Radiotherapy (SBRT)
-Magnetic Resonance Guided SBRT
-Radiofrequency Ablation
-Radiotherapy and Liver Recurrence
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
