Carbohydrates, or glycans, are the most abundant class of biomolecules on the planet that are known to play critical metabolic, structural, and functional roles in most known biological systems ranging from simple single cells to the largest known living organisms. Glycans have practical applications that range from producing a diverse range of bioproducts for everyday consumption as designer foods (e.g., prebiotics), renewable transportation fuels (e.g., plant-based biofuels), or advanced biomaterials (e.g., paper-based electronics, conductive textiles) to the development of more efficacious glycan-based biotherapeutics for the healthcare sector (e.g., glycoengineered monoclonal antibodies, antibody-drug conjugates). Glycobiotechnology has therefore emerged as an applied discipline over the last decade with rapid advances being made in the broader arena of glycosciences & glycobiology. This research topic will highlight the latest results on the frontiers of glycobiotechnology, spanning fundamental theory to methods & technology developments relevant to biopharmaceuticals, healthcare, medicine, and functional foods/nutrition-related areas.
The specific goals to be tackled by this Research Topic are to gain novel insights into the biological roles of glycans in general, enabled by recent advances in glycobiotechnology studies. Moreover, we wish to address the development of glycobiotechnology methods and tools such as high-throughput glycoanalytics. Additionally, the biosynthesis of functional glycans (for instance Human Milk Oligosaccharides, including precursors for efficient feedstock conversion), glycan precursors and glycoconjugates, are of importance to this topic. This also includes the development of automated or complex processes for their production on small and larger scales. Finally, we wish to address the development of novel technologies to gain control over the post-translational modification of glycoconjugates (e.g., glycoproteins, glycolipids, glycoRNA).
This collection welcomes Original Research, Review, Mini Review, and Perspectives on various aspects of glycobiotechnology. Areas of interest could include, but are not limited to:
•Fundamentals of Glycobiotechnology
-Impact of Protein Glycosylation on the Design of Biopharmaceuticals and Vaccines
-Novel Insight into the Role of Human Milk Oligosaccharides
-Advances in Glycoprotein Modeling
•Progress in Glycoanalytics
-High-Throughput Glycoanalytics for In-process Control
-Novel Technologies & Methods for Glycoanalytics
•Biosynthesis: (Chemo-)Enzymatic Methods and Metabolic Engineering of Cells
-Biocatalytic Synthesis of Glycans and Nucleotide Sugars
-Synthesis of Human Milk Oligosaccharides
-Design of Glycoconjugate Vaccines
-Automated Synthesis and Novel Processes
-Protein Engineering of Carbohydrate-active Enzymes
-New Systems for Glycan and Glycoconjugate Production
•Advances in Glycoengineering of Proteins
-Biocatalytic Glycoengineering, Glycosylation and Transglycosylaton
-Cell-free Glycoengineering
-Cell-based Glycoengineering
-Engineering of Glycolipids and other Novel Glycoconjugates (e.g., glycoRNA)
Carbohydrates, or glycans, are the most abundant class of biomolecules on the planet that are known to play critical metabolic, structural, and functional roles in most known biological systems ranging from simple single cells to the largest known living organisms. Glycans have practical applications that range from producing a diverse range of bioproducts for everyday consumption as designer foods (e.g., prebiotics), renewable transportation fuels (e.g., plant-based biofuels), or advanced biomaterials (e.g., paper-based electronics, conductive textiles) to the development of more efficacious glycan-based biotherapeutics for the healthcare sector (e.g., glycoengineered monoclonal antibodies, antibody-drug conjugates). Glycobiotechnology has therefore emerged as an applied discipline over the last decade with rapid advances being made in the broader arena of glycosciences & glycobiology. This research topic will highlight the latest results on the frontiers of glycobiotechnology, spanning fundamental theory to methods & technology developments relevant to biopharmaceuticals, healthcare, medicine, and functional foods/nutrition-related areas.
The specific goals to be tackled by this Research Topic are to gain novel insights into the biological roles of glycans in general, enabled by recent advances in glycobiotechnology studies. Moreover, we wish to address the development of glycobiotechnology methods and tools such as high-throughput glycoanalytics. Additionally, the biosynthesis of functional glycans (for instance Human Milk Oligosaccharides, including precursors for efficient feedstock conversion), glycan precursors and glycoconjugates, are of importance to this topic. This also includes the development of automated or complex processes for their production on small and larger scales. Finally, we wish to address the development of novel technologies to gain control over the post-translational modification of glycoconjugates (e.g., glycoproteins, glycolipids, glycoRNA).
This collection welcomes Original Research, Review, Mini Review, and Perspectives on various aspects of glycobiotechnology. Areas of interest could include, but are not limited to:
•Fundamentals of Glycobiotechnology
-Impact of Protein Glycosylation on the Design of Biopharmaceuticals and Vaccines
-Novel Insight into the Role of Human Milk Oligosaccharides
-Advances in Glycoprotein Modeling
•Progress in Glycoanalytics
-High-Throughput Glycoanalytics for In-process Control
-Novel Technologies & Methods for Glycoanalytics
•Biosynthesis: (Chemo-)Enzymatic Methods and Metabolic Engineering of Cells
-Biocatalytic Synthesis of Glycans and Nucleotide Sugars
-Synthesis of Human Milk Oligosaccharides
-Design of Glycoconjugate Vaccines
-Automated Synthesis and Novel Processes
-Protein Engineering of Carbohydrate-active Enzymes
-New Systems for Glycan and Glycoconjugate Production
•Advances in Glycoengineering of Proteins
-Biocatalytic Glycoengineering, Glycosylation and Transglycosylaton
-Cell-free Glycoengineering
-Cell-based Glycoengineering
-Engineering of Glycolipids and other Novel Glycoconjugates (e.g., glycoRNA)