MiRNAs are small non-coding RNAs that regulate the majority of the coding transcriptome in humans. Mature miRNAs associate to Argonaute (AGO) proteins to form the RNA-induced silencing complex (RISC) and target mRNA 3'UTRs. MiRNA- guided gene silencing promotes both mRNA decay and translational inhibition. Since miRNA's discovery almost 30 years ago, studies have been focused in understanding miRNA mechanisms of action and biogenesis, as well as pathways regulated by miRNAs and their potential role in diagnose and therapy of different diseases. Expression studies have allowed to observe broad alterations of miRNAs under different physiological and pathological conditions, which supports their participation in all cellular processes.
Evidence shows that miRNAs respond to different environmental stimuli, such as oxidative stress, metabolic alterations, and viral and bacterial infections regulating gene expression in different cell types and organisms. The high stability of miRNAs compared to other RNA species and its rapid expression when required make them key molecules that finely control mRNA and protein levels, and ultimately the cellular response to diverse clues including stress. These characteristics and the regulatory networks that miRNAs establish interacting with other non-coding RNAs such as linear lncRNAs and circRNAs, are critical for neuronal function, death and survival and are increasingly recognized as associated with age-related neurodegenerative diseases.
The aim of this Research Topic is collecting articles that use cellular and animal models to examine miRNAs as molecules able to quickly respond to normal and disease-related alterations in the neuronal environment, through modifications in expression, chemical tags, localization, interactions with targets and non-coding RNA networks, leading to the regulation of genes linked to neuronal function and neurodegeneration.
We are interested in collecting research and review articles that include the following themes:
- Regulation of genes related to neuronal function and neurodegeneration through response of miRNA to metabolites, heavy metals, oxidative stress, fungi, bacterial and viral infections, among others. These studies might include miRNA alterations at the level of expression, chemical modifications, cellular and subcellular localization and mRNA targets, among others.
- Networks between miRNAs, lncRNAs and circRNAs and other non-coding RNAs in different types of neuronal cells, that participate in neuronal function, death and survival, especially if they are associated to neurodegenerative diseases.
MiRNAs are small non-coding RNAs that regulate the majority of the coding transcriptome in humans. Mature miRNAs associate to Argonaute (AGO) proteins to form the RNA-induced silencing complex (RISC) and target mRNA 3'UTRs. MiRNA- guided gene silencing promotes both mRNA decay and translational inhibition. Since miRNA's discovery almost 30 years ago, studies have been focused in understanding miRNA mechanisms of action and biogenesis, as well as pathways regulated by miRNAs and their potential role in diagnose and therapy of different diseases. Expression studies have allowed to observe broad alterations of miRNAs under different physiological and pathological conditions, which supports their participation in all cellular processes.
Evidence shows that miRNAs respond to different environmental stimuli, such as oxidative stress, metabolic alterations, and viral and bacterial infections regulating gene expression in different cell types and organisms. The high stability of miRNAs compared to other RNA species and its rapid expression when required make them key molecules that finely control mRNA and protein levels, and ultimately the cellular response to diverse clues including stress. These characteristics and the regulatory networks that miRNAs establish interacting with other non-coding RNAs such as linear lncRNAs and circRNAs, are critical for neuronal function, death and survival and are increasingly recognized as associated with age-related neurodegenerative diseases.
The aim of this Research Topic is collecting articles that use cellular and animal models to examine miRNAs as molecules able to quickly respond to normal and disease-related alterations in the neuronal environment, through modifications in expression, chemical tags, localization, interactions with targets and non-coding RNA networks, leading to the regulation of genes linked to neuronal function and neurodegeneration.
We are interested in collecting research and review articles that include the following themes:
- Regulation of genes related to neuronal function and neurodegeneration through response of miRNA to metabolites, heavy metals, oxidative stress, fungi, bacterial and viral infections, among others. These studies might include miRNA alterations at the level of expression, chemical modifications, cellular and subcellular localization and mRNA targets, among others.
- Networks between miRNAs, lncRNAs and circRNAs and other non-coding RNAs in different types of neuronal cells, that participate in neuronal function, death and survival, especially if they are associated to neurodegenerative diseases.