Fracture healing is a complex physiological process of repair in which bone forms under a series of events including both mechanical and biological aspects. Although bone regeneration is a process involved in continuous remodeling throughout adult life, there are complex clinical conditions that require large quantity of bone regeneration.
In developed countries, approximately one in 100 inhabitants suffer a fracture each year. Among these, fractures fail to heal in 5%-10% of the cases. Impaired bone healing has a deleterious social impact on quality of life and carries a substantial cost to society worldwide.
The bone healing process is tightly regulated by a series of distinct cellular responses under the control of specific intracellular signaling pathways. Even though this is a well-orchestrated series of biological events, many factors can interrupt the normal flow of these signaling pathways.
Although aging is the most common reason for impaired bone healing, several other diseases and conditions may increase the risk of nonunion, independent of the individual’s age. Individuals affected by diabetes, anemia, or infection have a higher risk of nonunion upon fractures. The mechanisms and characteristics leading to impaired bone healing vary according to the pathogenesis of the primary osteometabolic disfunction. Bone disuse is a key factor in the pathogenesis of impaired union in several neurological diseases affecting mobility, such as spinal cord injury, cerebral palsy, and stroke, as well as during long-term bed rest, immobilization, or due to microgravity exposure.
This Research Topic provides insight into pathogenesis and the risk factors leading to impaired bone healing, as well as an overview of the current therapeutic approaches.
We welcome the submission of basic and clinical original research, reviews/mini-reviews, perspectives, and opinion articles on the contribution of the “Impaired bone healing due to bone disuse and osteometabolic disorders” by researchers in endocrine, orthopedics, and related fields. We accept manuscripts related to, but not limited to, the following themes:
• The mechanisms and characteristics of callus formation in a scenario of bone loss due to bone disuse (i.e., spinal cord injury, cerebral palsy, stroke, long-term bed rest or immobilization, microgravity exposure) or osteometabolic disorders (i.e., diabetes, osteomalacia, osteopetrosis).
• Preventive or therapeutical approaches to improve bone repair.
Fracture healing is a complex physiological process of repair in which bone forms under a series of events including both mechanical and biological aspects. Although bone regeneration is a process involved in continuous remodeling throughout adult life, there are complex clinical conditions that require large quantity of bone regeneration.
In developed countries, approximately one in 100 inhabitants suffer a fracture each year. Among these, fractures fail to heal in 5%-10% of the cases. Impaired bone healing has a deleterious social impact on quality of life and carries a substantial cost to society worldwide.
The bone healing process is tightly regulated by a series of distinct cellular responses under the control of specific intracellular signaling pathways. Even though this is a well-orchestrated series of biological events, many factors can interrupt the normal flow of these signaling pathways.
Although aging is the most common reason for impaired bone healing, several other diseases and conditions may increase the risk of nonunion, independent of the individual’s age. Individuals affected by diabetes, anemia, or infection have a higher risk of nonunion upon fractures. The mechanisms and characteristics leading to impaired bone healing vary according to the pathogenesis of the primary osteometabolic disfunction. Bone disuse is a key factor in the pathogenesis of impaired union in several neurological diseases affecting mobility, such as spinal cord injury, cerebral palsy, and stroke, as well as during long-term bed rest, immobilization, or due to microgravity exposure.
This Research Topic provides insight into pathogenesis and the risk factors leading to impaired bone healing, as well as an overview of the current therapeutic approaches.
We welcome the submission of basic and clinical original research, reviews/mini-reviews, perspectives, and opinion articles on the contribution of the “Impaired bone healing due to bone disuse and osteometabolic disorders” by researchers in endocrine, orthopedics, and related fields. We accept manuscripts related to, but not limited to, the following themes:
• The mechanisms and characteristics of callus formation in a scenario of bone loss due to bone disuse (i.e., spinal cord injury, cerebral palsy, stroke, long-term bed rest or immobilization, microgravity exposure) or osteometabolic disorders (i.e., diabetes, osteomalacia, osteopetrosis).
• Preventive or therapeutical approaches to improve bone repair.
