Allergies have become the leading chronic disease in many parts of the world, affecting up to 40% of the population worldwide, resulting in a silent pandemic. As a result, significant work has been focused in identifying and characterizing allergens in order to improve routine diagnosis and treatment. Recently, efforts have expanded to studying the role of lipids in modulating the allergenicity of proteins. Several allergens have now been shown to possess lipid cargos or ligands, such as triacylglycerols, phospholipids, cholesteryl ester, different fatty acids, palmitoyl-CoA, prostaglandin B2, and eicosanoid-like substances as well as lipid-conjugates, such as LPS, which may be partially or fully responsible for the allergic response. Further, lipids have been shown to bind to a large number of proteins which are considered major allergens. Thus, understanding the role of lipids in the development of allergies is very important.
This Research Topic intends to collect original research, methodology, opinion articles, review, and mini-review papers to provide a foundational presentation of the current breadth of lipids and lipid-conjugates that associate with allergens and influence allergic sensitization as well as current understanding of the molecular mechanisms involved in lipid-modulated allergic responses.
Areas to be covered in this Research Topic may include, but are not limited to:
• Lipids and lipid-conjugates that associate with allergens
• Lipids that induce or mediate in sensitization
• Lipids interacting with innate immune system and T cells
• Lipids engaging the Toll-like receptors
• Structure and characterization of lipophilic and hydrophobic allergens
• Methods to determine, predict, identify, and characterize their lipid ligands of allergens
• Approaches to determine lipid-modulated allergic response
• Therapeutic approaches to treat lipid-modulated allergic responses
Allergies have become the leading chronic disease in many parts of the world, affecting up to 40% of the population worldwide, resulting in a silent pandemic. As a result, significant work has been focused in identifying and characterizing allergens in order to improve routine diagnosis and treatment. Recently, efforts have expanded to studying the role of lipids in modulating the allergenicity of proteins. Several allergens have now been shown to possess lipid cargos or ligands, such as triacylglycerols, phospholipids, cholesteryl ester, different fatty acids, palmitoyl-CoA, prostaglandin B2, and eicosanoid-like substances as well as lipid-conjugates, such as LPS, which may be partially or fully responsible for the allergic response. Further, lipids have been shown to bind to a large number of proteins which are considered major allergens. Thus, understanding the role of lipids in the development of allergies is very important.
This Research Topic intends to collect original research, methodology, opinion articles, review, and mini-review papers to provide a foundational presentation of the current breadth of lipids and lipid-conjugates that associate with allergens and influence allergic sensitization as well as current understanding of the molecular mechanisms involved in lipid-modulated allergic responses.
Areas to be covered in this Research Topic may include, but are not limited to:
• Lipids and lipid-conjugates that associate with allergens
• Lipids that induce or mediate in sensitization
• Lipids interacting with innate immune system and T cells
• Lipids engaging the Toll-like receptors
• Structure and characterization of lipophilic and hydrophobic allergens
• Methods to determine, predict, identify, and characterize their lipid ligands of allergens
• Approaches to determine lipid-modulated allergic response
• Therapeutic approaches to treat lipid-modulated allergic responses
