Stroke is a major public health concern, affecting millions of people worldwide and ranking as the second leading cause of death and the third leading cause of disability around the world. Previously, the main focus of ischemic stroke research was on the central nervous system (CNS) aiming to rescue the damaged neurons on site of ischemic stroke. However, failure of neuroprotective treatments in clinical trials strongly suggests ischemic stroke is rather a sophisticatedly systemic disorder involving not only the nervous system. In fact, stroke exhibits multiphasic processes, including the progression of ischemic brain injury associated with intense and long-lasting innate and adaptive immune responses in the periphery and CNS. These immune responses are biologically distinguishable, providing a time frame for intervention and also represent a novel therapeutic target.
In this Research Topic, we aim to explore and highlight the comprehensive status of ischemic stroke as a systemic disorder involving dysfunctions in both the immune and nervous systems. This research topic will shed light on the role and mechanisms of the peripheral and CNS immune systems in the initiation, progression, and outcome of ischemic stroke. Additionally, we also focus on neuronal or immune biomarkers to assess the severity of ischemic stroke.
We welcome submissions of reviews, mini reviews, reports, and original research articles of preclinical and clinical research that cover, but are not limited to the following subtopics:
• The role and mechanisms of immune activations (both CNS and periphery) in the initiation of ischemic stroke
• How do systemic immune responses affect the CNS (neuronal damage/recovery) and periphery (peripheral organ dysfunctions) post-ischemic stroke?
• Mechanisms of peripheral organ dysfunctions that modulate the outcome of ischemic stroke through immune functions, involving intestinal-brain axis, spleen-brain axis, lung-brain axis, etc.
• The impact of stroke on neurodegeneration - long term effect of microglia/peripheral immune cells on neurodegeneration after stroke
• The identification of biomarkers in neuroimmunity, peripheral immune responses, and nervous system predicting the progression and severity of ischemic stroke
• Novel discoveries and clinical trials applying the immune therapies in ischemic stroke
• New technologies to investigate the neuro-immune responses induced by ischemic stroke (including but not limited to, single-cell/nuclei RNA sequencing, CyTOF, Cytec® Aurora)
Stroke is a major public health concern, affecting millions of people worldwide and ranking as the second leading cause of death and the third leading cause of disability around the world. Previously, the main focus of ischemic stroke research was on the central nervous system (CNS) aiming to rescue the damaged neurons on site of ischemic stroke. However, failure of neuroprotective treatments in clinical trials strongly suggests ischemic stroke is rather a sophisticatedly systemic disorder involving not only the nervous system. In fact, stroke exhibits multiphasic processes, including the progression of ischemic brain injury associated with intense and long-lasting innate and adaptive immune responses in the periphery and CNS. These immune responses are biologically distinguishable, providing a time frame for intervention and also represent a novel therapeutic target.
In this Research Topic, we aim to explore and highlight the comprehensive status of ischemic stroke as a systemic disorder involving dysfunctions in both the immune and nervous systems. This research topic will shed light on the role and mechanisms of the peripheral and CNS immune systems in the initiation, progression, and outcome of ischemic stroke. Additionally, we also focus on neuronal or immune biomarkers to assess the severity of ischemic stroke.
We welcome submissions of reviews, mini reviews, reports, and original research articles of preclinical and clinical research that cover, but are not limited to the following subtopics:
• The role and mechanisms of immune activations (both CNS and periphery) in the initiation of ischemic stroke
• How do systemic immune responses affect the CNS (neuronal damage/recovery) and periphery (peripheral organ dysfunctions) post-ischemic stroke?
• Mechanisms of peripheral organ dysfunctions that modulate the outcome of ischemic stroke through immune functions, involving intestinal-brain axis, spleen-brain axis, lung-brain axis, etc.
• The impact of stroke on neurodegeneration - long term effect of microglia/peripheral immune cells on neurodegeneration after stroke
• The identification of biomarkers in neuroimmunity, peripheral immune responses, and nervous system predicting the progression and severity of ischemic stroke
• Novel discoveries and clinical trials applying the immune therapies in ischemic stroke
• New technologies to investigate the neuro-immune responses induced by ischemic stroke (including but not limited to, single-cell/nuclei RNA sequencing, CyTOF, Cytec® Aurora)
