The brain is protected against harmful substances from the blood by three major barriers, the blood-brain barrier, the choroid plexus blood- cerebrospinal fluid barrier and the arachnoid blood-cerebrospinal fluid barrier. The blood-brain barrier is constituted on the level of endothelial cells of the brain capillaries. The epithelial cells of the choroid plexus form the choroid plexus blood-cerebrospinal fluid barrier. The arachnoid blood-cerebrospinal fluid barrier separates blood vessels from the cerebrospinal fluid in the subarachnoid space. The tight junctions are crucial components of these barriers responsible for their tightness. The role of the brain barriers in brain disorders (neurodegenerative, traumatic, oncologic, autoimmune, vascular, inflammatory) has been widely studied in past decades. It has been described that the brain barriers react during the aforementioned diseases by an inflammatory reaction and changing their permeability.
Despite extensive study of the brain barriers it is still unclear how their function could be used in treatment of the brain disorders. Especially, inflammatory reaction and a role of cytokines and chemokines in barrier affection should be elucidated in order to answer their impact on barrier function. Another important topic is the regulation of the tight junction proteins in the brain barriers as promising way for drug delivery. Therefore, the aim of this Research Topic is to provide a new insight into:
1. Inflammatory reactions in the brain barriers and their changes during the brain disorders
2. The brain barrier modulation for drug delivery and treatment.
In this Research Topic, we welcome original research and review articles related to the reaction of the brain barriers to brain disorders and their modulation for drug delivery and treatment. Potential topics include, but are not limited to:
• The brain barriers in neurodegenerative disorders
• The brain barriers in brain trauma
• The brain barriers in neuroinflammation
• The brain barriers in primary cancers and cancer metastasis
• The brain barriers in autoimmunity
• The brain barriers in stroke and subarachnoid hemorrhage
• Modulation of the brain barriers for drug delivery
The brain is protected against harmful substances from the blood by three major barriers, the blood-brain barrier, the choroid plexus blood- cerebrospinal fluid barrier and the arachnoid blood-cerebrospinal fluid barrier. The blood-brain barrier is constituted on the level of endothelial cells of the brain capillaries. The epithelial cells of the choroid plexus form the choroid plexus blood-cerebrospinal fluid barrier. The arachnoid blood-cerebrospinal fluid barrier separates blood vessels from the cerebrospinal fluid in the subarachnoid space. The tight junctions are crucial components of these barriers responsible for their tightness. The role of the brain barriers in brain disorders (neurodegenerative, traumatic, oncologic, autoimmune, vascular, inflammatory) has been widely studied in past decades. It has been described that the brain barriers react during the aforementioned diseases by an inflammatory reaction and changing their permeability.
Despite extensive study of the brain barriers it is still unclear how their function could be used in treatment of the brain disorders. Especially, inflammatory reaction and a role of cytokines and chemokines in barrier affection should be elucidated in order to answer their impact on barrier function. Another important topic is the regulation of the tight junction proteins in the brain barriers as promising way for drug delivery. Therefore, the aim of this Research Topic is to provide a new insight into:
1. Inflammatory reactions in the brain barriers and their changes during the brain disorders
2. The brain barrier modulation for drug delivery and treatment.
In this Research Topic, we welcome original research and review articles related to the reaction of the brain barriers to brain disorders and their modulation for drug delivery and treatment. Potential topics include, but are not limited to:
• The brain barriers in neurodegenerative disorders
• The brain barriers in brain trauma
• The brain barriers in neuroinflammation
• The brain barriers in primary cancers and cancer metastasis
• The brain barriers in autoimmunity
• The brain barriers in stroke and subarachnoid hemorrhage
• Modulation of the brain barriers for drug delivery
