Epilepsy is a chronic neurological disease and is induced by an abnormal neuronal discharge that is caused by complicated psychopathologies. Its clinical manifestations include recurrent seizures, convulsions and changes in consciousness drastically affecting the quality of life of those afflicted with this disorder. There are 65 million people worldwide who currently suffer from epilepsy. New-onset symptomatic epilepsy can be caused be developmental disorders, skull fractures, haemorrhage as well as other inflictions such as strokes. Understanding the molecular mechanisms that contribute to epilepsy pathology is essential to the identification of potential therapeutics and biomarkers to treat epilepsy.
The goal of this Research Topic is to further understand the diverse and complex molecular mechanisms that contribute to epilepsy pathology. This will range from inflammatory cells and their role in pathogenesis and development to post-traumatic epilepsy resulting from traumatic brain injury.
This Research Topic will welcome submissions on studies investigating the molecular mechanisms of epilepsy as well as potential therapeutics.
Topics of interest include, but are not limited to:
• The role of the inflammatory and immune response in epilepsy development
• Mechanisms behind new-onset symptomatic epilepsy including post-traumatic epilepsy
• How epileptiform activity alters gene expression
• Studies on transcriptome-wide and cell-specific changes with the goal to reveal novel candidates involved in pathophysiology of epilepsy
• Potential therapeutics for the treatment of epilepsy
Epilepsy is a chronic neurological disease and is induced by an abnormal neuronal discharge that is caused by complicated psychopathologies. Its clinical manifestations include recurrent seizures, convulsions and changes in consciousness drastically affecting the quality of life of those afflicted with this disorder. There are 65 million people worldwide who currently suffer from epilepsy. New-onset symptomatic epilepsy can be caused be developmental disorders, skull fractures, haemorrhage as well as other inflictions such as strokes. Understanding the molecular mechanisms that contribute to epilepsy pathology is essential to the identification of potential therapeutics and biomarkers to treat epilepsy.
The goal of this Research Topic is to further understand the diverse and complex molecular mechanisms that contribute to epilepsy pathology. This will range from inflammatory cells and their role in pathogenesis and development to post-traumatic epilepsy resulting from traumatic brain injury.
This Research Topic will welcome submissions on studies investigating the molecular mechanisms of epilepsy as well as potential therapeutics.
Topics of interest include, but are not limited to:
• The role of the inflammatory and immune response in epilepsy development
• Mechanisms behind new-onset symptomatic epilepsy including post-traumatic epilepsy
• How epileptiform activity alters gene expression
• Studies on transcriptome-wide and cell-specific changes with the goal to reveal novel candidates involved in pathophysiology of epilepsy
• Potential therapeutics for the treatment of epilepsy
