In response to tissue injury inflammatory reactions occur that aim to restore homeostasis. However, hampered resolution of inflammation can result in pathologic wound repair. These pathologic conditions can be the result of excessive oxidative and inflammatory stress and/or overwhelmed adaptive response systems. It can also be triggered by a variety of other conditions including diabetes, infections, or aging. Inducing cytoprotective systems may ameliorate exacerbation of injury and prevent pathologic wound repair and fibrosis. These systems include antioxidant, anti-inflammatory, anti-apoptotic enzymes, transporters, channels, and protective molecules. In this topic, we intend to bring together these different cytoprotective mechanisms and discuss about possible cross-talk between these different systems. Better insight into the observed differences between pre-conditioning and post-conditioning in relation to tissue repair could further deepen our understanding. We expect that learning more about the molecular mechanisms protecting against tissue injury will enable the development of better strategies to prevent or ameliorate wound repair and promote healthy aging.
In response to tissue injury inflammatory reactions occur that aim to restore homeostasis. However, hampered resolution of inflammation can result in pathologic wound repair. These pathologic conditions can be the result of excessive oxidative and inflammatory stress and/or overwhelmed adaptive response systems. It can also be triggered by a variety of other conditions including diabetes, infections, or aging. Inducing cytoprotective systems may ameliorate exacerbation of injury and prevent pathologic wound repair and fibrosis. These systems include antioxidant, anti-inflammatory, anti-apoptotic enzymes, transporters, channels, and protective molecules. In this topic, we intend to bring together these different cytoprotective mechanisms and discuss about possible cross-talk between these different systems. Better insight into the observed differences between pre-conditioning and post-conditioning in relation to tissue repair could further deepen our understanding. We expect that learning more about the molecular mechanisms protecting against tissue injury will enable the development of better strategies to prevent or ameliorate wound repair and promote healthy aging.
