Adult stem cells are a group of stem cells present in postnatal tissues. They are responsible for postnatal regeneration and important cell sources for regenerative medicine. Adult stem cells, like hematopoietic stem cells, muscle stem cells, and skin stem cells, go through stemness maintenance and differentiation during the process of regeneration. Upon aging, the activity of adult stem cells declines which is attributed to the reduced regeneration ability in the aged population. Adult stem cells undergo different epigenetic and transcription regulation processes during regeneration and aging. Revealing the mechanism of the epigenetic and transcriptional regulation of adult stem cells during regeneration and aging will broaden the horizon for our understanding of cell fate determination.
Though many studies have been performed to address the epigenetic and transcription regulation of stem cells, most of them have been done in embryonic stem cells (ES cells). Adult stem cells represent stem cells existing in the postnatal organism. They are non-tumorigenic and have great potential in regenerative medicine applications. Though some rules learned from ES cells can also be applied to adult stem cells, there are many unique regulatory mechanisms involved in the cell fate determination of adult stem cells. Furthermore, each type of adult stem cell may use different regulation strategies to govern their stemness maintenance, self-renewal, proliferation, differentiation, and aging. These mechanisms remain to be fully uncovered.
The topic welcomes submissions which include, but are not limited to, the following themes:
1. The epigenetic regulation of adult stem cells: including DNA modification, RNA modification, Histone modification, in adult stem cell stemness maintenance, self-renewal, proliferation, differentiation, and aging
2. The chromatin structure regulation in adult stem cell stemness maintenance, self-renewal, proliferation, differentiation, and aging
3. The functions of key transcription factors and co-factors in adult stem cell stemness maintenance, self-renewal, proliferation, differentiation, and aging
Adult stem cells are a group of stem cells present in postnatal tissues. They are responsible for postnatal regeneration and important cell sources for regenerative medicine. Adult stem cells, like hematopoietic stem cells, muscle stem cells, and skin stem cells, go through stemness maintenance and differentiation during the process of regeneration. Upon aging, the activity of adult stem cells declines which is attributed to the reduced regeneration ability in the aged population. Adult stem cells undergo different epigenetic and transcription regulation processes during regeneration and aging. Revealing the mechanism of the epigenetic and transcriptional regulation of adult stem cells during regeneration and aging will broaden the horizon for our understanding of cell fate determination.
Though many studies have been performed to address the epigenetic and transcription regulation of stem cells, most of them have been done in embryonic stem cells (ES cells). Adult stem cells represent stem cells existing in the postnatal organism. They are non-tumorigenic and have great potential in regenerative medicine applications. Though some rules learned from ES cells can also be applied to adult stem cells, there are many unique regulatory mechanisms involved in the cell fate determination of adult stem cells. Furthermore, each type of adult stem cell may use different regulation strategies to govern their stemness maintenance, self-renewal, proliferation, differentiation, and aging. These mechanisms remain to be fully uncovered.
The topic welcomes submissions which include, but are not limited to, the following themes:
1. The epigenetic regulation of adult stem cells: including DNA modification, RNA modification, Histone modification, in adult stem cell stemness maintenance, self-renewal, proliferation, differentiation, and aging
2. The chromatin structure regulation in adult stem cell stemness maintenance, self-renewal, proliferation, differentiation, and aging
3. The functions of key transcription factors and co-factors in adult stem cell stemness maintenance, self-renewal, proliferation, differentiation, and aging