Prediabetes affects about one-third of adults in the US and more than one-fifth of adults in Europe. Prediabetes often presents with other features of the metabolic syndrome such as hypertension, dyslipidemia, and obesity which contributes to the increased morbidity and mortality. Nonetheless, prediabetes has been independently associated with increased risk of developing diabetes and with increased risk of having adverse cardiovascular events, including a higher risk of coronary heart disease, stroke and heart failure. A higher prevalence of microvascular complications has also been observed among patients with prediabetes. Prediabetes remains a underdiagnosed condition, and therapeutic strategies to reduce progression to diabetes and to reduce micro- and macrovascular complications remain limited and underused.
The goals of this research topic are:
1) Foster the development of new diagnostic tools to identify individuals with prediabetes (eg. new approaches to OGTT, metabolomics, genomics, the use of CGM for classifying glycemic status, …).
2) Promote the development of risk stratification tools for prediabetes (eg. risk calculators to identify the risk of development of diabetes, cardiovascular disease and/or microvascular disease).
3) Promote the evaluation in prediabetes of the potential benefits of new drugs and interventions used for treatment of diabetes (eg. SGLT2 inhibithors, GLP-1 agonists, twincretins and multiagonists; or metabolic surgery; …)
4) Evaluate the relevance of comorbidities (obesity, hypertension, dyslipidemia, …) among patients with prediabetes and the role of individualization of diagnostic and therapeutic approaches to these conditions in prediabetes.
search topic is designed to aggregate multiple different approaches to the field of prediabetes. This includes retrospective and prospective clinical studies, epidemiological studies, randomized clinical trials, basic and translational studies, systematic reviews, meta-analysis and narrative reviews. Collaborative papers between different specialties and fields, and between different institutions are encouraged. The manuscripts should address one or more goals of this research topic (diagnosis, risk stratification, comorbidities, cardiovascular disease, microvascular disease, treatment, and translation to real-world practice of new advances in prediabetes field).
Prediabetes affects about one-third of adults in the US and more than one-fifth of adults in Europe. Prediabetes often presents with other features of the metabolic syndrome such as hypertension, dyslipidemia, and obesity which contributes to the increased morbidity and mortality. Nonetheless, prediabetes has been independently associated with increased risk of developing diabetes and with increased risk of having adverse cardiovascular events, including a higher risk of coronary heart disease, stroke and heart failure. A higher prevalence of microvascular complications has also been observed among patients with prediabetes. Prediabetes remains a underdiagnosed condition, and therapeutic strategies to reduce progression to diabetes and to reduce micro- and macrovascular complications remain limited and underused.
The goals of this research topic are:
1) Foster the development of new diagnostic tools to identify individuals with prediabetes (eg. new approaches to OGTT, metabolomics, genomics, the use of CGM for classifying glycemic status, …).
2) Promote the development of risk stratification tools for prediabetes (eg. risk calculators to identify the risk of development of diabetes, cardiovascular disease and/or microvascular disease).
3) Promote the evaluation in prediabetes of the potential benefits of new drugs and interventions used for treatment of diabetes (eg. SGLT2 inhibithors, GLP-1 agonists, twincretins and multiagonists; or metabolic surgery; …)
4) Evaluate the relevance of comorbidities (obesity, hypertension, dyslipidemia, …) among patients with prediabetes and the role of individualization of diagnostic and therapeutic approaches to these conditions in prediabetes.
search topic is designed to aggregate multiple different approaches to the field of prediabetes. This includes retrospective and prospective clinical studies, epidemiological studies, randomized clinical trials, basic and translational studies, systematic reviews, meta-analysis and narrative reviews. Collaborative papers between different specialties and fields, and between different institutions are encouraged. The manuscripts should address one or more goals of this research topic (diagnosis, risk stratification, comorbidities, cardiovascular disease, microvascular disease, treatment, and translation to real-world practice of new advances in prediabetes field).
