microRNAs (miRNAs) are a type of small, non-coding RNA; they are responsible for regulating mRNA, typically as a mediator of its degradation or through regulation of transcription and translation. miRNA is involved in various metabolic signalling pathways that affect gene regulation, such as the EGFR, PI3K/Akt, MAPK, STAT3, and Notch pathways. The regulation of intracellular signalling pathways is vital for the maintenance and development of the normal cell; errors within these pathways can result in significant dysfunction. Certain miRNAs can be affected by epigenetic changes or abnormalities in genetic machinery that cause them to act as oncogenes, encouraging tumour cell proliferation. However, there is also evidence that dysregulation in these miRNAs can give them a tumour suppressing effect. Research that leads to greater understanding of miRNAs, and their significance as prognostic biomarkers, may aid in improved patient diagnosis and treatment.
Biomarkers are excellent research targets because they can lead to earlier diagnosis and improved patient outcomes. miRNAs are have been identified as having significant potential as predictive biomarkers. Alteration of regulatory mechanisms can lead to the overexpression or downregulation of miRNAs, which then exacerbate tumour progression. It can also cause miRNAs to act as tumour suppressors. It is vital greater understanding is achieved into which miRNAs can have these effects, and how their influence on signalling pathways result in these outcomes. The goal of this Research Topic is to gather studies on the relationship between miRNAs and their ability to act as tumour suppressors or oncogenes. This will ideally give us insight into their clinical significance as prognostic biomarkers, and potentially identify avenues for further research. Additionally, this RT is not limited to a certain type of cancer, which means that the role of miRNAs in different kinds of tumours can be examined.
The scope of this topic is research on microRNA dysregulation in cellular metabolic signalling pathways. This will be in relation to their role in tumour progression or suppression. We would like manuscripts to contribute to the understanding of miRNA networks, by identifying signalling pathways that could be targeted as predictive biomarkers in cancer suppression/progression. Manuscripts may indicate how this information could be utilized in clinical settings. We are interested in primary research articles, review articles, and systematic reviews and meta-analyses.
Themes:
-miRNA as a therapeutic biomarker in any cancer type
-miRNA influencing signalling pathways leads to multiple carcinomas
-Studies on miRNA prognostic significance on tumour progression or tumour suppression
microRNAs (miRNAs) are a type of small, non-coding RNA; they are responsible for regulating mRNA, typically as a mediator of its degradation or through regulation of transcription and translation. miRNA is involved in various metabolic signalling pathways that affect gene regulation, such as the EGFR, PI3K/Akt, MAPK, STAT3, and Notch pathways. The regulation of intracellular signalling pathways is vital for the maintenance and development of the normal cell; errors within these pathways can result in significant dysfunction. Certain miRNAs can be affected by epigenetic changes or abnormalities in genetic machinery that cause them to act as oncogenes, encouraging tumour cell proliferation. However, there is also evidence that dysregulation in these miRNAs can give them a tumour suppressing effect. Research that leads to greater understanding of miRNAs, and their significance as prognostic biomarkers, may aid in improved patient diagnosis and treatment.
Biomarkers are excellent research targets because they can lead to earlier diagnosis and improved patient outcomes. miRNAs are have been identified as having significant potential as predictive biomarkers. Alteration of regulatory mechanisms can lead to the overexpression or downregulation of miRNAs, which then exacerbate tumour progression. It can also cause miRNAs to act as tumour suppressors. It is vital greater understanding is achieved into which miRNAs can have these effects, and how their influence on signalling pathways result in these outcomes. The goal of this Research Topic is to gather studies on the relationship between miRNAs and their ability to act as tumour suppressors or oncogenes. This will ideally give us insight into their clinical significance as prognostic biomarkers, and potentially identify avenues for further research. Additionally, this RT is not limited to a certain type of cancer, which means that the role of miRNAs in different kinds of tumours can be examined.
The scope of this topic is research on microRNA dysregulation in cellular metabolic signalling pathways. This will be in relation to their role in tumour progression or suppression. We would like manuscripts to contribute to the understanding of miRNA networks, by identifying signalling pathways that could be targeted as predictive biomarkers in cancer suppression/progression. Manuscripts may indicate how this information could be utilized in clinical settings. We are interested in primary research articles, review articles, and systematic reviews and meta-analyses.
Themes:
-miRNA as a therapeutic biomarker in any cancer type
-miRNA influencing signalling pathways leads to multiple carcinomas
-Studies on miRNA prognostic significance on tumour progression or tumour suppression