The complement system is an important part of the innate immune system, linking the innate and adaptive immune responses. Serving as one of the first lines of defense, it protects the host by recognizing and eliminating foreign pathogens. The complement system is composed of three pathways, the classical pathway (CP), the alternative pathway (AP), and the lectin pathway (LP), and more than 50 regulated proteins, making it a complex part of the immune system. Therefore, when this complex system is dysregulated or overwhelmed, it can induce inflammatory immune responses in the host.
The kidney is an organ that is particularly susceptible to damage by dysregulation of the complement system. Therefore, it is not surprising that the pathogenesis of several kidney diseases results from abnormal activation of the complement system. Complement dysregulation is characteristic of the renal disease atypical hemolytic uremic syndrome (aHUS) and complement C3 glomerulopathy (C3G).
This Research Topic aims to improve our understanding of the role of complement in kidney aetiologies such as aHUS and C3G. We will welcome submissions which are focusing on the activation and inhibition complement pathways, their regulation, and the involved receptors, specifically in kidney diseases. Related to this, an understanding of the regulation and cross-talk of complement pathways and other signaling cascades may provide a wider picture of immunopathogenesis of kidney diseases. This information will be important in improving and guiding the current/future development of complement therapeutics and other related immunotherapeutics aimed at treating kidney diseases.
In this Research Topic, we welcome the submission of Original Research, Review, Mini Review, Perspective, and Case Report articles focusing on Complement and Kidney Diseases. We welcome submissions covering, but not limited to, the following sub-topics:
• Complement activation and inhibition (CP, LP, AP) in kidney diseases
• Complement regulation in kidney diseases
• Specific complement receptors involved in the pathogenesis of kidney diseases
• Cross-talk of complement with other endogenous signaling cascades in the pathogenesis of kidney diseases
• Genetics of complement and kidney diseases
• Complement pathways activated in COVID-19 kidneys and differences in individuals with kidney disease
• Complement immunotherapies for the treatment of kidney diseases
The complement system is an important part of the innate immune system, linking the innate and adaptive immune responses. Serving as one of the first lines of defense, it protects the host by recognizing and eliminating foreign pathogens. The complement system is composed of three pathways, the classical pathway (CP), the alternative pathway (AP), and the lectin pathway (LP), and more than 50 regulated proteins, making it a complex part of the immune system. Therefore, when this complex system is dysregulated or overwhelmed, it can induce inflammatory immune responses in the host.
The kidney is an organ that is particularly susceptible to damage by dysregulation of the complement system. Therefore, it is not surprising that the pathogenesis of several kidney diseases results from abnormal activation of the complement system. Complement dysregulation is characteristic of the renal disease atypical hemolytic uremic syndrome (aHUS) and complement C3 glomerulopathy (C3G).
This Research Topic aims to improve our understanding of the role of complement in kidney aetiologies such as aHUS and C3G. We will welcome submissions which are focusing on the activation and inhibition complement pathways, their regulation, and the involved receptors, specifically in kidney diseases. Related to this, an understanding of the regulation and cross-talk of complement pathways and other signaling cascades may provide a wider picture of immunopathogenesis of kidney diseases. This information will be important in improving and guiding the current/future development of complement therapeutics and other related immunotherapeutics aimed at treating kidney diseases.
In this Research Topic, we welcome the submission of Original Research, Review, Mini Review, Perspective, and Case Report articles focusing on Complement and Kidney Diseases. We welcome submissions covering, but not limited to, the following sub-topics:
• Complement activation and inhibition (CP, LP, AP) in kidney diseases
• Complement regulation in kidney diseases
• Specific complement receptors involved in the pathogenesis of kidney diseases
• Cross-talk of complement with other endogenous signaling cascades in the pathogenesis of kidney diseases
• Genetics of complement and kidney diseases
• Complement pathways activated in COVID-19 kidneys and differences in individuals with kidney disease
• Complement immunotherapies for the treatment of kidney diseases
