Sepsis is a systemic inflammatory response to an active infectious process in the host; the symptoms are mainly produced by host defense systems rather than by the invading pathogens, involving pro-inflammatory and anti-inflammatory processes. The association of Acute Kidney Injury (AKI) and sepsis ranges from 45% to 70% of cases, with a significantly increased risk of death, progression toward chronic kidney disease and increased health resource utilization.
Despite relevant therapeutic advances, sepsis-related AKI remains associated with an unacceptably high morbidity/mortality risk, increased health resource utilization, as well as - in survivors - with increased risk of transition to chronic kidney disease. Currently there are no approved treatments for sepsis-related AKI. The main objective of this research topic is to shed new light on sepsis pathogenesis and provide new potential therapeutic strategies to prevent the progression to AKI.
In this Research Topic we welcome submissions of Original Research and Review articles on the following sub-topics:
• To explore new pathogenic mechanisms of sepsis-induced AKI, with special regard to the role of soluble/cellular components of innate immunity, focusing on activation of Complement system and immune cells.
• To identify new therapeutic approaches that could modulate the DAMPs response, recovering the immune-regulatory network.
• To define early and reliable biomarkers for risk assessment, diagnosis, prognosis, and response to therapy in sepsis related-AKI.
• Preclinical and translational studies will improve current knowledge
Sepsis is a systemic inflammatory response to an active infectious process in the host; the symptoms are mainly produced by host defense systems rather than by the invading pathogens, involving pro-inflammatory and anti-inflammatory processes. The association of Acute Kidney Injury (AKI) and sepsis ranges from 45% to 70% of cases, with a significantly increased risk of death, progression toward chronic kidney disease and increased health resource utilization.
Despite relevant therapeutic advances, sepsis-related AKI remains associated with an unacceptably high morbidity/mortality risk, increased health resource utilization, as well as - in survivors - with increased risk of transition to chronic kidney disease. Currently there are no approved treatments for sepsis-related AKI. The main objective of this research topic is to shed new light on sepsis pathogenesis and provide new potential therapeutic strategies to prevent the progression to AKI.
In this Research Topic we welcome submissions of Original Research and Review articles on the following sub-topics:
• To explore new pathogenic mechanisms of sepsis-induced AKI, with special regard to the role of soluble/cellular components of innate immunity, focusing on activation of Complement system and immune cells.
• To identify new therapeutic approaches that could modulate the DAMPs response, recovering the immune-regulatory network.
• To define early and reliable biomarkers for risk assessment, diagnosis, prognosis, and response to therapy in sepsis related-AKI.
• Preclinical and translational studies will improve current knowledge
