Probiotics-Modulated Intestinal Immunity against Infectious Diseases in Animals

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College of Animal Science & Technology • College of Veterinary Medicine, Zhejiang A&F University

Northeast Agricultural University

Changyong Cheng

College of Animal Science & Technology • College of Veterinary Medicine, Zhejiang A & F University

Luis G. Bermudez

Institut National de recherche pour l’agriculture, l’alimentation et l’environnement (INRAE)

College of Animal Science and Technology, Jilin Agriculture University

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Enteropathogens (bacteria and viruses) infect animals mainly by invading the digestive tract. They propagate in the animal intestines, damage the intestinal mucosal tissues, and cause intestinal dysfunction and damage. The diseases of the animals have resulted in huge economic loss in livestock and poultry industry. As a part of body's immune networks, the intestinal tract plays an important role in fighting against the bacterial and viral infections. Probiotics (e.g., yeasts, probiotic Bacillus, Clostridium butyricum, Lactobacillus, and Bifidobacterium) have many beneficial biological effects on the host, such as promoting digestion and absorption of the nutrients, improving hosts’ immunity, and improving the body's antioxidant level. Probiotics are also known to protect the intestinal mucosal barrier. They can help fight infections and maintain intestinal health by regulating the hosts’ intestinal immune system or by balancing the intestinal microbiome flora. Towards the advancement of the fundamental knowledge and exploration of the applications of probiotics in animal health, it is of great significance to explore the molecular mechanism of the host-probiotics interaction.

This Research Topic is to provide a platform for presenting and discussing the cutting-edge research on all aspects of probiotics modulating the intestinal immunity against bacterial and viral infectious disease in animals. We welcome manuscripts from, but not limited to, the following subtopics:

• Host-probiotics interactions against intestinal infection
• Probiotics-intestinal microbiota interactions
• Role of probiotics in animal intestinal health and diseases
• Identification and mechanisms of probiotics metabolites modulating host immunity
• Integrative transcriptomics and proteomics of probiotics modulating host immunity
• Development of oral mucosal vaccine using the probiotics as antigen delivery vector

Enteropathogens (bacteria and viruses) infect animals mainly by invading the digestive tract. They propagate in the animal intestines, damage the intestinal mucosal tissues, and cause intestinal dysfunction and damage. The diseases of the animals have resulted in huge economic loss in livestock and poultry industry. As a part of body's immune networks, the intestinal tract plays an important role in fighting against the bacterial and viral infections. Probiotics (e.g., yeasts, probiotic Bacillus, Clostridium butyricum, Lactobacillus, and Bifidobacterium) have many beneficial biological effects on the host, such as promoting digestion and absorption of the nutrients, improving hosts’ immunity, and improving the body's antioxidant level. Probiotics are also known to protect the intestinal mucosal barrier. They can help fight infections and maintain intestinal health by regulating the hosts’ intestinal immune system or by balancing the intestinal microbiome flora. Towards the advancement of the fundamental knowledge and exploration of the applications of probiotics in animal health, it is of great significance to explore the molecular mechanism of the host-probiotics interaction.

This Research Topic is to provide a platform for presenting and discussing the cutting-edge research on all aspects of probiotics modulating the intestinal immunity against bacterial and viral infectious disease in animals. We welcome manuscripts from, but not limited to, the following subtopics:

• Host-probiotics interactions against intestinal infection
• Probiotics-intestinal microbiota interactions
• Role of probiotics in animal intestinal health and diseases
• Identification and mechanisms of probiotics metabolites modulating host immunity
• Integrative transcriptomics and proteomics of probiotics modulating host immunity
• Development of oral mucosal vaccine using the probiotics as antigen delivery vector

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Editors

College of Animal Science & Technology • College of Veterinary Medicine, Zhejiang A&F University

Northeast Agricultural University

Changyong Cheng

College of Animal Science & Technology • College of Veterinary Medicine, Zhejiang A & F University

Luis G. Bermudez

Institut National de recherche pour l’agriculture, l’alimentation et l’environnement (INRAE)

College of Animal Science and Technology, Jilin Agriculture University

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Frontiers in Immunology

Microbial Immunology, Comparative Immunology

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Frontiers in Microbiology

Microbial Immunology

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