Post-transductional modifications are a key regulatory event for many biological processes and their de-regulation is closely associated with cancer. In this context, Sumoylation represents a less known post-transduction modification respect to Ubiquitination, but certainly equally important. Sumoylation is a reversible post-translational modification in which a small ubiquitin-like modifier (SUMO) is covalently conjugated to a lysine residue in a target protein. This provides an efficient way to modulate the subcellular localization, activity, and stability of a wide variety of substrates Its involvement is known in the neuro-degeneration process and in immune reactivity, but very little is known about its involvement in cancer.
The goal of this research topic is to identify the involvement of Sumoylation in the processes that lead to the onset of cancer. To do this, it will be appropriate to study various oncological pathologies (both solid tumors and blood cancers) to identify the involvement of Sumoylation in carcinogenesis. This will need to be done by identifying the sumoylated targets in the cells and by determining if the sumoylation levels of these targets differ between the sick and healthy conditions. Furthermore, it will be necessary to identify any regulators of this process to evaluate any therapies aimed at reducing or re-activating the Sumoylation process according to the identified target.
The scopes of this Research Topic are:
• Identification of new actors in Sumoylation process in cancer.
• Evaluation of Sumoylation process in Haematological cancer and/or solid cancers.
• Correlation of Sumoylation and cancer processes.
• Identification of new molecules able to modified the Sumoylation process for therapeutic purposes.
• Characterization of specific Sumoylation profiles for diagnostics purposes.
The types of manuscripts the Editor are interested are:
• Full articles
• Reviews
Post-transductional modifications are a key regulatory event for many biological processes and their de-regulation is closely associated with cancer. In this context, Sumoylation represents a less known post-transduction modification respect to Ubiquitination, but certainly equally important. Sumoylation is a reversible post-translational modification in which a small ubiquitin-like modifier (SUMO) is covalently conjugated to a lysine residue in a target protein. This provides an efficient way to modulate the subcellular localization, activity, and stability of a wide variety of substrates Its involvement is known in the neuro-degeneration process and in immune reactivity, but very little is known about its involvement in cancer.
The goal of this research topic is to identify the involvement of Sumoylation in the processes that lead to the onset of cancer. To do this, it will be appropriate to study various oncological pathologies (both solid tumors and blood cancers) to identify the involvement of Sumoylation in carcinogenesis. This will need to be done by identifying the sumoylated targets in the cells and by determining if the sumoylation levels of these targets differ between the sick and healthy conditions. Furthermore, it will be necessary to identify any regulators of this process to evaluate any therapies aimed at reducing or re-activating the Sumoylation process according to the identified target.
The scopes of this Research Topic are:
• Identification of new actors in Sumoylation process in cancer.
• Evaluation of Sumoylation process in Haematological cancer and/or solid cancers.
• Correlation of Sumoylation and cancer processes.
• Identification of new molecules able to modified the Sumoylation process for therapeutic purposes.
• Characterization of specific Sumoylation profiles for diagnostics purposes.
The types of manuscripts the Editor are interested are:
• Full articles
• Reviews