The COVID-19 pandemic continues to have a tremendous impact on health in 2021; and continues to affect many lives, living conditions and society in almost every country on this planet. Since early 2020, much scientific literature has been published regarding nutrient deficiencies (such as vitamins C, D, E and minerals such as zinc, among others) affecting the severity of disease outcomes, as well as possible mechanistic roles of nutrients and bioactive compounds theorized for early prophylaxis and adjunctive treatment of the clinical symptoms of the disease process. But in this second year of the pandemic, are we sufficiently at the stage for prescribing food nutraceuticals as medicine in the treatment of COVID-19?
The interaction between COVID-19 inflammation and oxidative stress is a vicious circle towards organ damage. And it is well accepted that essential micronutrients that support the antioxidant defense system are generally depleted in serious diseases. In addition, older adults with co-morbid conditions of chronic disease and suboptimal nutrient intakes carry a greater burden of chronic basal inflammation, which is a poor prognosis for the progression of COVID-19. Supplementing certain nutrients during the treatment of the COVID-19 viral infection may help strengthen the immune system, prevent the spread of the virus, preclude the disease from progressing to a serious stage, and further suppress excessive inflammation, thereby bearing medicinal benefit.
In this Research Topic denoting nutraceuticals adjuvant treatment involving nutrients and bioactive compounds as prescription aiding the recovery process of the COVID-19 disease, we invite Original Research articles and Reviews that will contribute significantly to the knowledge gap in the adjunctive therapy management of the disease. Importantly, we invite contributions based on clinical trials as we have sufficiently advanced in the management of infectious disease to generate evidence-based treatment strategies.
This Research Topic should achieve some of the listed bullet points below:
• Clinical trials (single or multicentered, randomized, or retrospective patient cohorts) that provide definitive evidence for the treatment process of the COVID-19 infection involving nutraceutical agents.
• Molecular scientific approaches contributing to foundational and functional understanding for treatment approaches based on nutraceutical approaches.
• Reviews that weigh the evidence for the treatment process of the COVID-19 infection involving nutraceutical agents.
• Explore mechanistic links between micronutrients, hyper-inflammation (cytokine storms), excessive oxidative stress, dysregulated immune function, and COVID-19 infection.
• To clarify nutraceutical roles for vitamins B, C, D, E, zinc, selenium, omega-3 fatty acids, melatonin, quercetin, lactoferrin and other bioactive molecules having anti-oxidative and immunomodulatory effects, with numerous benefits across different age groups and co-morbidities of COVID-19.
The COVID-19 pandemic continues to have a tremendous impact on health in 2021; and continues to affect many lives, living conditions and society in almost every country on this planet. Since early 2020, much scientific literature has been published regarding nutrient deficiencies (such as vitamins C, D, E and minerals such as zinc, among others) affecting the severity of disease outcomes, as well as possible mechanistic roles of nutrients and bioactive compounds theorized for early prophylaxis and adjunctive treatment of the clinical symptoms of the disease process. But in this second year of the pandemic, are we sufficiently at the stage for prescribing food nutraceuticals as medicine in the treatment of COVID-19?
The interaction between COVID-19 inflammation and oxidative stress is a vicious circle towards organ damage. And it is well accepted that essential micronutrients that support the antioxidant defense system are generally depleted in serious diseases. In addition, older adults with co-morbid conditions of chronic disease and suboptimal nutrient intakes carry a greater burden of chronic basal inflammation, which is a poor prognosis for the progression of COVID-19. Supplementing certain nutrients during the treatment of the COVID-19 viral infection may help strengthen the immune system, prevent the spread of the virus, preclude the disease from progressing to a serious stage, and further suppress excessive inflammation, thereby bearing medicinal benefit.
In this Research Topic denoting nutraceuticals adjuvant treatment involving nutrients and bioactive compounds as prescription aiding the recovery process of the COVID-19 disease, we invite Original Research articles and Reviews that will contribute significantly to the knowledge gap in the adjunctive therapy management of the disease. Importantly, we invite contributions based on clinical trials as we have sufficiently advanced in the management of infectious disease to generate evidence-based treatment strategies.
This Research Topic should achieve some of the listed bullet points below:
• Clinical trials (single or multicentered, randomized, or retrospective patient cohorts) that provide definitive evidence for the treatment process of the COVID-19 infection involving nutraceutical agents.
• Molecular scientific approaches contributing to foundational and functional understanding for treatment approaches based on nutraceutical approaches.
• Reviews that weigh the evidence for the treatment process of the COVID-19 infection involving nutraceutical agents.
• Explore mechanistic links between micronutrients, hyper-inflammation (cytokine storms), excessive oxidative stress, dysregulated immune function, and COVID-19 infection.
• To clarify nutraceutical roles for vitamins B, C, D, E, zinc, selenium, omega-3 fatty acids, melatonin, quercetin, lactoferrin and other bioactive molecules having anti-oxidative and immunomodulatory effects, with numerous benefits across different age groups and co-morbidities of COVID-19.
