Cerebral ischemia is a major disease in the world, which has become a serious threat to human life and health. However, in clinical practice, except for thrombolytic drugs, other available drugs for the treatment of cerebral ischemia are extremely limited. Because neuroprotection is an important strategy for cerebral ischemia treatment, the research and development of neuroprotective agents have always been the focus in this field. Neuroprotective agents can interfere with various pathophysiological processes, such as calcium overload, free radical-mediated cytotoxicity, inflammatory reactions, excitotoxicity, destruction of the blood-brain barrier and so on. Calcium channel blockers, antioxidants, anti-inflammatory agents, excitatory amino acid antagonists and apoptosis inhibitors are the main kinds of neuroprotective agents. At present, after thousands of experimental studies and clinical trials, only a very small number of neuroprotective agents, such as edaravone and butylphthalide, have been approved. It will be a long-term research task to deeply study the molecular mechanisms of ischemia-induced neuronal damage, explore new prevention and treatment strategies and technologies, and develop new neuroprotective agents for the prevention and treatment of cerebral ischemia.
In recent years, many new kinds of compounds have been reported as neuroprotective agents for the treatment of cerebral ischemia and showed significant therapeutic effects against ischemic damage both in vivo and in vitro. The underlying mechanisms included for neuroprotection may be inhibiting inflammatory reactions, preventing oxidative stress, reducing excitotoxic damage, acting on multiple targets, promoting the long-term recovery of neurobehavioral function and so on. The aims of this research topic are to update the current understanding and future directions of the research and development of neuroprotective agents. We will gladly consider original researches, reviews, perspectives, and commentaries about related research on new kinds of neuroprotective agents with significant advantages for cerebral ischemia treatment.
Potential topics include but are not limited to the following:
- Research on novel neuroprotective agents developed based on new mechanisms or new targets
- Studies on novel neuroprotective agents acting on multiple targets
- Novel neuroprotective agents with wide therapeutic time windows
- New mechanisms of the existing neuroprotective agents
- Therapeutic effects of combination therapies of neuroprotective agents on ischemic damage
- Effects of neuroprotective agents on the long-term recovery of neurobehavioral function
- Comparative study of neuroprotective agents
Cerebral ischemia is a major disease in the world, which has become a serious threat to human life and health. However, in clinical practice, except for thrombolytic drugs, other available drugs for the treatment of cerebral ischemia are extremely limited. Because neuroprotection is an important strategy for cerebral ischemia treatment, the research and development of neuroprotective agents have always been the focus in this field. Neuroprotective agents can interfere with various pathophysiological processes, such as calcium overload, free radical-mediated cytotoxicity, inflammatory reactions, excitotoxicity, destruction of the blood-brain barrier and so on. Calcium channel blockers, antioxidants, anti-inflammatory agents, excitatory amino acid antagonists and apoptosis inhibitors are the main kinds of neuroprotective agents. At present, after thousands of experimental studies and clinical trials, only a very small number of neuroprotective agents, such as edaravone and butylphthalide, have been approved. It will be a long-term research task to deeply study the molecular mechanisms of ischemia-induced neuronal damage, explore new prevention and treatment strategies and technologies, and develop new neuroprotective agents for the prevention and treatment of cerebral ischemia.
In recent years, many new kinds of compounds have been reported as neuroprotective agents for the treatment of cerebral ischemia and showed significant therapeutic effects against ischemic damage both in vivo and in vitro. The underlying mechanisms included for neuroprotection may be inhibiting inflammatory reactions, preventing oxidative stress, reducing excitotoxic damage, acting on multiple targets, promoting the long-term recovery of neurobehavioral function and so on. The aims of this research topic are to update the current understanding and future directions of the research and development of neuroprotective agents. We will gladly consider original researches, reviews, perspectives, and commentaries about related research on new kinds of neuroprotective agents with significant advantages for cerebral ischemia treatment.
Potential topics include but are not limited to the following:
- Research on novel neuroprotective agents developed based on new mechanisms or new targets
- Studies on novel neuroprotective agents acting on multiple targets
- Novel neuroprotective agents with wide therapeutic time windows
- New mechanisms of the existing neuroprotective agents
- Therapeutic effects of combination therapies of neuroprotective agents on ischemic damage
- Effects of neuroprotective agents on the long-term recovery of neurobehavioral function
- Comparative study of neuroprotective agents