Constipation is a common gastrointestinal disorder with a high prevalence rate worldwide. It may occur in men and women of any age. Approximately 14% of the general population suffers from constipation. Patients with constipation usually have prolonged emptying time of the gastrointestinal tract, low-frequency and incomplete defecation. With the alternation of dietary habits, lifestyle, and psychological factors, the incidence of constipation is increasing worldwide. Although some irritant drugs have been used in the treatment of constipation, they have limited efficacy and result in many adverse effects. Probiotics refer to live micro-organisms that, when administered in adequate amounts, confer health benefits to the host. Oral probiotic supplements are considered to be safe and long-acting. Over the past decade, there has been an increase in research investigating the effects of the improvements of probiotics in constipation. Currently, many animal and clinical studies have confirmed the promising effects of several probiotics in the treatment of constipation. Because of the species and strain specificity of probiotics, the isolation, identification and effectiveness evaluation of novel probiotics that improve constipation is still necessary. Furthermore, the underlying mechanisms by which probiotics alleviate constipation have not been fully clarified.
This Research Topic aims to provide the current advances about probiotics and constipation, with a particular focus on the in vivo relieving effects and mechanisms of fermented food-derived novel probiotics on constipation.
In the current Research Topic, we warmly welcome and encourage the manuscripts that are associated with the following sub-topics. The type of submissions is limited to the Original Research article and Review article.
• The isolation and identification of fermented food-derived novel probiotics that could alleviate constipation;
• The improvement effects of probiotics on constipation in animal experiments and clinical trials;
• The innovative mechanisms that aim to clarify the relieving effect of probiotics on constipation;
• The development of in vitro experimental model for the screening of the probiotics with the improvement of constipation.
This Research Topic aims to collect publications relevant to human nutrition only. Studies on farm animals other than animal models for human nutrition will not be accepted in this Research Topic and will be re-directed to other relevant Frontiers journals.
Constipation is a common gastrointestinal disorder with a high prevalence rate worldwide. It may occur in men and women of any age. Approximately 14% of the general population suffers from constipation. Patients with constipation usually have prolonged emptying time of the gastrointestinal tract, low-frequency and incomplete defecation. With the alternation of dietary habits, lifestyle, and psychological factors, the incidence of constipation is increasing worldwide. Although some irritant drugs have been used in the treatment of constipation, they have limited efficacy and result in many adverse effects. Probiotics refer to live micro-organisms that, when administered in adequate amounts, confer health benefits to the host. Oral probiotic supplements are considered to be safe and long-acting. Over the past decade, there has been an increase in research investigating the effects of the improvements of probiotics in constipation. Currently, many animal and clinical studies have confirmed the promising effects of several probiotics in the treatment of constipation. Because of the species and strain specificity of probiotics, the isolation, identification and effectiveness evaluation of novel probiotics that improve constipation is still necessary. Furthermore, the underlying mechanisms by which probiotics alleviate constipation have not been fully clarified.
This Research Topic aims to provide the current advances about probiotics and constipation, with a particular focus on the in vivo relieving effects and mechanisms of fermented food-derived novel probiotics on constipation.
In the current Research Topic, we warmly welcome and encourage the manuscripts that are associated with the following sub-topics. The type of submissions is limited to the Original Research article and Review article.
• The isolation and identification of fermented food-derived novel probiotics that could alleviate constipation;
• The improvement effects of probiotics on constipation in animal experiments and clinical trials;
• The innovative mechanisms that aim to clarify the relieving effect of probiotics on constipation;
• The development of in vitro experimental model for the screening of the probiotics with the improvement of constipation.
This Research Topic aims to collect publications relevant to human nutrition only. Studies on farm animals other than animal models for human nutrition will not be accepted in this Research Topic and will be re-directed to other relevant Frontiers journals.