Protein sequences must be folded and sorted to correct subcellular organelles before they can perform their molecular functions in a subcellular biological process. Therefore, pinpointing the subcellular location of a protein is an important step to understanding its functional role.
Over the last two decades, many efforts have been made in computationally predicting protein subcellular locations. However, with the accumulation of recent high-throughput image-based data, many more methods and models are developed. Particularly, the relationships between the subcellular location alteration and complex disorders are still not fully understood.
This research topic intends to be an international forum for presenting up-to-date computational studies that are related to protein subcellular localizations. Topics of interest include, but are not limited to the following aspects:
• Computational prediction of protein subcellular / sub-subcellular locations
• Computational modelling of protein sorting process
• Automatic image processing methods for identifying protein subcellular locations
• Relationships between protein mis-localizations and complex disorders
• Spatial proteomics based biomarker identifications
• Systems biology model for protein sorting process
The Topic Editors would like to acknowledge Dr Wanwen Zeng (Stanford University, USA) who has acted as coordinator. Dr. Zeng has contributed to the preparation of the proposal for this Research Topic.
Protein sequences must be folded and sorted to correct subcellular organelles before they can perform their molecular functions in a subcellular biological process. Therefore, pinpointing the subcellular location of a protein is an important step to understanding its functional role.
Over the last two decades, many efforts have been made in computationally predicting protein subcellular locations. However, with the accumulation of recent high-throughput image-based data, many more methods and models are developed. Particularly, the relationships between the subcellular location alteration and complex disorders are still not fully understood.
This research topic intends to be an international forum for presenting up-to-date computational studies that are related to protein subcellular localizations. Topics of interest include, but are not limited to the following aspects:
• Computational prediction of protein subcellular / sub-subcellular locations
• Computational modelling of protein sorting process
• Automatic image processing methods for identifying protein subcellular locations
• Relationships between protein mis-localizations and complex disorders
• Spatial proteomics based biomarker identifications
• Systems biology model for protein sorting process
The Topic Editors would like to acknowledge Dr Wanwen Zeng (Stanford University, USA) who has acted as coordinator. Dr. Zeng has contributed to the preparation of the proposal for this Research Topic.
