Colorectal cancer is one of the most prevalent malignancies, known as the third most common cancer and a leading cause of global mortality. Despite advances in treatment and therapies for colorectal cancer patients, prognosis and overall survival rate remain poor. The primary reason is due to the challenges in early detection where colorectal cancer is asymptomatic until patients reach an advanced stage of the disease. Furthermore, approximately more than 50% of advanced-stage patients suffer from metastasis and recurrence. Treatment for colorectal cancer patients typically involve surgery, which could be curative in the early-stage setting, chemotherapy and radiotherapy which generally improve clinical outcomes but are not curative and the incidence of recurrence still remains high. Therefore, early detection is crucial as well as the identification of non-invasive diagnostic biomarkers able to predict prognosis and/or response to treatment .
MicroRNAs (miRNAs) are small non-coding RNAs that modulate gene expression in both cells and tissues by targeting mRNA or inhibiting protein biosynthesis, therefore regulating cell growth and development. Studies have demonstrated the influence of miRNAs in the development of tumors and therefore are identified as potential diagnostic novel biomarkers for developing new therapies. Recent studies have focused on miR-1539 to understand its functionality in various types of cancer. It was discovered to be differentially expressed in colorectal cancer tumors which suggests it has a key role in the progression of the disease, prompting further research. Other studies have suggested miR-122, miR-200c and miR-338 as diagnostic biomarkers as they have proven to be promising in predicting tumorigenesis and prognosis. Further miRNAs including miR-425 and miR-576 are being studied to understand their impact in colorectal cancer.
This Research Topic aims to highlight the influences of miRNAs in the progression of colorectal cancer and the potential of miRNAs as novel diagnostic biomarkers. We welcome Original Research Articles, Review Articles and Systematic Reviews.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Colorectal cancer is one of the most prevalent malignancies, known as the third most common cancer and a leading cause of global mortality. Despite advances in treatment and therapies for colorectal cancer patients, prognosis and overall survival rate remain poor. The primary reason is due to the challenges in early detection where colorectal cancer is asymptomatic until patients reach an advanced stage of the disease. Furthermore, approximately more than 50% of advanced-stage patients suffer from metastasis and recurrence. Treatment for colorectal cancer patients typically involve surgery, which could be curative in the early-stage setting, chemotherapy and radiotherapy which generally improve clinical outcomes but are not curative and the incidence of recurrence still remains high. Therefore, early detection is crucial as well as the identification of non-invasive diagnostic biomarkers able to predict prognosis and/or response to treatment .
MicroRNAs (miRNAs) are small non-coding RNAs that modulate gene expression in both cells and tissues by targeting mRNA or inhibiting protein biosynthesis, therefore regulating cell growth and development. Studies have demonstrated the influence of miRNAs in the development of tumors and therefore are identified as potential diagnostic novel biomarkers for developing new therapies. Recent studies have focused on miR-1539 to understand its functionality in various types of cancer. It was discovered to be differentially expressed in colorectal cancer tumors which suggests it has a key role in the progression of the disease, prompting further research. Other studies have suggested miR-122, miR-200c and miR-338 as diagnostic biomarkers as they have proven to be promising in predicting tumorigenesis and prognosis. Further miRNAs including miR-425 and miR-576 are being studied to understand their impact in colorectal cancer.
This Research Topic aims to highlight the influences of miRNAs in the progression of colorectal cancer and the potential of miRNAs as novel diagnostic biomarkers. We welcome Original Research Articles, Review Articles and Systematic Reviews.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.