Chronic kidney disease (CKD) is a debilitating pathological condition with various causal factors, culminating in end-stage renal disease (ESRD) which requires urgent attention in the form of dialysis or kidney transplantation. CKD is common and can be found in up to a quarter of patients with diabetes. Diabetes management includes many areas that may be influenced by the severity of a patient's kidney dysfunction. The progression of CKD is closely associated with systemic inflammation and oxidative stress, which are responsible for the manifestation of numerous complications such as malnutrition, atherosclerosis, coronary artery calcification, heart failure, anemia, and mineral and bone disorders, as well as enhanced cardiovascular mortality.
Amassing evidence has described coordinated crosstalk between inflammation and oxidative stress in initiating metabolic dysfunction, including diabetes and diabetes-associated complications, which contributes towards the development of CKD. On the other hand, increased prevalence of insulin resistance (a prediabetes condition) and diabetes has reached epidemic proportions. Many factors contribute to the chronic inflammatory state in CKD, including the increased production of pro-inflammatory cytokines and oxidative stress, as well as acidosis, chronic and recurrent infections, intestinal dysbiosis, and altered adipose tissue metabolism. It is important to recognize the impact of this deadly combination of diabetes and CKD as identification and diagnosis is paramount to optimize clinical management recommendations for this complex patient population. This Special Issue aims to highlight the bidirectional relationship between inflammation and oxidative stress and their role in the pathophysiology and treatment of diabetes and CKD.
Specifically, this Research Topic entitled “The role of Oxidative Stress and Systemic Inflammation in Diabetes and Chronic Kidney Disease” solicits original research and review articles on topics including but not restricted to the role and contribution of oxidative stress and inflammation in diabetes and chronic kidney disease. Research related to metabolism may be broadly defined (e.g., biomarkers and processes related to metabolic disorders; interventions or lifestyle factors such as diet and exercise; cellular metabolism and mitochondrial function), and all manuscripts should include the measurement of (or discussion of for reviews) at least one aspect of inflammation or oxidative stress.
Chronic kidney disease (CKD) is a debilitating pathological condition with various causal factors, culminating in end-stage renal disease (ESRD) which requires urgent attention in the form of dialysis or kidney transplantation. CKD is common and can be found in up to a quarter of patients with diabetes. Diabetes management includes many areas that may be influenced by the severity of a patient's kidney dysfunction. The progression of CKD is closely associated with systemic inflammation and oxidative stress, which are responsible for the manifestation of numerous complications such as malnutrition, atherosclerosis, coronary artery calcification, heart failure, anemia, and mineral and bone disorders, as well as enhanced cardiovascular mortality.
Amassing evidence has described coordinated crosstalk between inflammation and oxidative stress in initiating metabolic dysfunction, including diabetes and diabetes-associated complications, which contributes towards the development of CKD. On the other hand, increased prevalence of insulin resistance (a prediabetes condition) and diabetes has reached epidemic proportions. Many factors contribute to the chronic inflammatory state in CKD, including the increased production of pro-inflammatory cytokines and oxidative stress, as well as acidosis, chronic and recurrent infections, intestinal dysbiosis, and altered adipose tissue metabolism. It is important to recognize the impact of this deadly combination of diabetes and CKD as identification and diagnosis is paramount to optimize clinical management recommendations for this complex patient population. This Special Issue aims to highlight the bidirectional relationship between inflammation and oxidative stress and their role in the pathophysiology and treatment of diabetes and CKD.
Specifically, this Research Topic entitled “The role of Oxidative Stress and Systemic Inflammation in Diabetes and Chronic Kidney Disease” solicits original research and review articles on topics including but not restricted to the role and contribution of oxidative stress and inflammation in diabetes and chronic kidney disease. Research related to metabolism may be broadly defined (e.g., biomarkers and processes related to metabolic disorders; interventions or lifestyle factors such as diet and exercise; cellular metabolism and mitochondrial function), and all manuscripts should include the measurement of (or discussion of for reviews) at least one aspect of inflammation or oxidative stress.
