Arthropod-borne viruses (Arboviruses) are a group of genetically unrelated single-stranded RNA viruses that infect humans and animals worldwide, causing very diverse diseases. The infections associated with these viruses are among the leading causes of morbidity and mortality in developing countries. Interestingly, in the last decades, the world has seen the emergence of epidemic outbreaks due to new arboviruses, as observed in 2016 by Zika and two years earlier by Chikungunya and Mayaro viruses. However, annually up to 400 million people are infected with the most relevant arboviruses distributed globally, such Dengue virus. Finally, attention should focus on the new arbovirus that are emerging and establishing in geographical areas not previously detected. An example of this is Mayaro virus and the Oropuche virus. Notably, some treatments or vaccines are unavailable to date to control the infection for arboviruses; in addition, immunologic phenomenons such as antibody dependent-enhanced in flavivirus have become challenging to develop vaccines. The interplay between the vector and the mammalian host is of importance to culminate in a successful infection. Therefore, it is essential to understand the cellular, molecular, and immunological mechanisms that this virus evokes in these two biological systems.
Previous studies have found that arboviruses can disrupt various cellular processes, such as the control of metabolic pathways, evasion of innate immunity pathways, restructuring of the cellular architecture for the generation of replication complexes, participation in the nucleo-cytoplasm dynamic, regulation of gene expression, evolutionary mechanisms for adaptation or permissiveness to new tissues, or viral competition during coinfections. However, continuing with research to decipher and understand these mechanisms in greater depth is of utmost importance, thereby developing future alternatives for controlling and restricting this type of viral infection.
In this Research Topic, we aim to publish studies on new cellular, molecular, and immunologic mechanisms involved in virus-host and virus–vector interactions and the pathogenesis of arboviruses in humans and animals, including newly emerging one's arboviruses. Original Research papers, Review articles, and Opinions are welcome.
Arthropod-borne viruses (Arboviruses) are a group of genetically unrelated single-stranded RNA viruses that infect humans and animals worldwide, causing very diverse diseases. The infections associated with these viruses are among the leading causes of morbidity and mortality in developing countries. Interestingly, in the last decades, the world has seen the emergence of epidemic outbreaks due to new arboviruses, as observed in 2016 by Zika and two years earlier by Chikungunya and Mayaro viruses. However, annually up to 400 million people are infected with the most relevant arboviruses distributed globally, such Dengue virus. Finally, attention should focus on the new arbovirus that are emerging and establishing in geographical areas not previously detected. An example of this is Mayaro virus and the Oropuche virus. Notably, some treatments or vaccines are unavailable to date to control the infection for arboviruses; in addition, immunologic phenomenons such as antibody dependent-enhanced in flavivirus have become challenging to develop vaccines. The interplay between the vector and the mammalian host is of importance to culminate in a successful infection. Therefore, it is essential to understand the cellular, molecular, and immunological mechanisms that this virus evokes in these two biological systems.
Previous studies have found that arboviruses can disrupt various cellular processes, such as the control of metabolic pathways, evasion of innate immunity pathways, restructuring of the cellular architecture for the generation of replication complexes, participation in the nucleo-cytoplasm dynamic, regulation of gene expression, evolutionary mechanisms for adaptation or permissiveness to new tissues, or viral competition during coinfections. However, continuing with research to decipher and understand these mechanisms in greater depth is of utmost importance, thereby developing future alternatives for controlling and restricting this type of viral infection.
In this Research Topic, we aim to publish studies on new cellular, molecular, and immunologic mechanisms involved in virus-host and virus–vector interactions and the pathogenesis of arboviruses in humans and animals, including newly emerging one's arboviruses. Original Research papers, Review articles, and Opinions are welcome.