It is becoming increasingly clear that cell types in the brain cannot be studied in isolation. Recent discoveries in basic and translational neuroscience have led to increased interest in understanding how different cell types in the brain (e.g. neurons, astrocytes, microglia and oligodendrocytes) are working together to maintain healthy brain activity and accomplish higher brain functions, such as memory and cognition. Neuron-glia interactions are required throughout life, from the early stages of the development to the late stages of aging. At the same time, disrupted neuron-glia crosstalk emerges as important contributor to brain disorders, such as Alzheimer’s disease, epilepsy, or schizophrenia. Thus, a better understanding of the intercellular communication within the brain could hold clues for future treatment strategies of various neurological conditions.
This Research Topic aims to showcase the latest developments in the dynamic neuron-glia crosstalk field of research. It will provide an overview of the intercellular communication taking place in the brain, from the molecular biology to systems biology and behaviour, as well as highlight pathological conditions characterized by disrupted neuron-glia interactions in various organisms, such as mice, monkeys, or humans. As the intercellular communication within the brain is controlled by a range of both intra- and intercellular mechanisms, with deep implication for the health of the brain, it is of uttermost importance to perfect our understanding of the neuron-glia communication in all its aspects.
For this Research Topic, we welcome Original work, Methods, Perspectives and Reviews focusing on the interaction between neurons and glial cells, both in vitro and in vivo, including, but not limited to:
? The interaction between neurons and other brain cell types (astrocyte, microglia, oligodendrocyte) during development and healthy aging
? The role of neuron-glia crosstalk in pathological conditions
? Development of novel tools and models aimed to investigate the neuron-glia communication.
? Therapeutic interventions aimed to re-establish the neuron-glia interaction
It is becoming increasingly clear that cell types in the brain cannot be studied in isolation. Recent discoveries in basic and translational neuroscience have led to increased interest in understanding how different cell types in the brain (e.g. neurons, astrocytes, microglia and oligodendrocytes) are working together to maintain healthy brain activity and accomplish higher brain functions, such as memory and cognition. Neuron-glia interactions are required throughout life, from the early stages of the development to the late stages of aging. At the same time, disrupted neuron-glia crosstalk emerges as important contributor to brain disorders, such as Alzheimer’s disease, epilepsy, or schizophrenia. Thus, a better understanding of the intercellular communication within the brain could hold clues for future treatment strategies of various neurological conditions.
This Research Topic aims to showcase the latest developments in the dynamic neuron-glia crosstalk field of research. It will provide an overview of the intercellular communication taking place in the brain, from the molecular biology to systems biology and behaviour, as well as highlight pathological conditions characterized by disrupted neuron-glia interactions in various organisms, such as mice, monkeys, or humans. As the intercellular communication within the brain is controlled by a range of both intra- and intercellular mechanisms, with deep implication for the health of the brain, it is of uttermost importance to perfect our understanding of the neuron-glia communication in all its aspects.
For this Research Topic, we welcome Original work, Methods, Perspectives and Reviews focusing on the interaction between neurons and glial cells, both in vitro and in vivo, including, but not limited to:
? The interaction between neurons and other brain cell types (astrocyte, microglia, oligodendrocyte) during development and healthy aging
? The role of neuron-glia crosstalk in pathological conditions
? Development of novel tools and models aimed to investigate the neuron-glia communication.
? Therapeutic interventions aimed to re-establish the neuron-glia interaction