Breast cancer (BC) is the most common cancer and the leading cause of cancer death for women, accounting for 24.2% of total cancer cases and 15.0% of total cancer deaths. For early stage, localized diagnosis, the 5 year survival rate for BC is 99%. This significantly decreases to 28% for later-stage, distant diagnoses. This shows the importance of early detection in improving outcomes for patients. Therefore, understanding the etiology and identifying novel prognostic factors for diagnosis is vital.
The risk for BC increases with age, with most cases being diagnosed after 50. Other nonmodifiable risk factors include mutations to certain genes, such as BRCA1 and BRCA2, a family history of BC or ovarian cancer, and radiation therapy to the chest or breasts before age 30. Furthermore, lifestyle factors such as obesity post-menopause, taking hormone replacement therapies during menopause and physical inactivity can increase the risk of BC.
This Research Topic aims to strengthen the understanding of BC epidemiology and prevention strategies to aid in early detection and diagnosis and improve survival outcomes for patients. We welcome papers on the following topics:
- Incidence, mortality and survival for BC
- Etiology of BC
- Modifiable and Nonmodifiable risk factors for BC
- Prevention strategies and screening for BC
- Risk of second primary malignancies in BC patients
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases, eg. SEER, which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in this section.
Breast cancer (BC) is the most common cancer and the leading cause of cancer death for women, accounting for 24.2% of total cancer cases and 15.0% of total cancer deaths. For early stage, localized diagnosis, the 5 year survival rate for BC is 99%. This significantly decreases to 28% for later-stage, distant diagnoses. This shows the importance of early detection in improving outcomes for patients. Therefore, understanding the etiology and identifying novel prognostic factors for diagnosis is vital.
The risk for BC increases with age, with most cases being diagnosed after 50. Other nonmodifiable risk factors include mutations to certain genes, such as BRCA1 and BRCA2, a family history of BC or ovarian cancer, and radiation therapy to the chest or breasts before age 30. Furthermore, lifestyle factors such as obesity post-menopause, taking hormone replacement therapies during menopause and physical inactivity can increase the risk of BC.
This Research Topic aims to strengthen the understanding of BC epidemiology and prevention strategies to aid in early detection and diagnosis and improve survival outcomes for patients. We welcome papers on the following topics:
- Incidence, mortality and survival for BC
- Etiology of BC
- Modifiable and Nonmodifiable risk factors for BC
- Prevention strategies and screening for BC
- Risk of second primary malignancies in BC patients
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases, eg. SEER, which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in this section.