Role of Microbiome in Disease Diagnostics and Therapeutics

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About this Research Topic

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Background

Human microbiome explorations have enriched our understanding of the establishment, colonization, and maturation of the microbiome through continuous host microbiome interactions. Technological advancements have allowed us to unveil the key features of a resilient microbiome for human health. This extensive knowledge of the human microbiome is increasing the scope for disease diagnosis, testing, data collection, and disease therapeutics through microbiome modulation. The potential to engineer the whole microbial community or an individual microbial strain for health and disease is also being realized. Microbial metabolites, the whole microbiome, or an individual microbe are now being used to treat and diagnose different diseases. Moreover, studies are being carried out to decode illness specific microbial markers for diseases prognosis and diagnostics. There is a mounting interest of medical professionals from almost all disciplines for an accurate and replicable microbiome profiling for use in diagnostic and therapeutic application.

In the past few years, efforts are being made to develop microbe-based disease diagnostics and therapeutics. The enormous metabolic potential of gut microbes and their role in the maintenance of human health has emerged as a new research avenue. Even the global microbiome therapeutics market size was valued at USD 11.3 million in 2015, which is expected to surpass US$ 890 million by 2025 end. In this context microbiome based diseases diagnostics and therapeutics would be of extreme interest to the researchers, medical professionals, and biotechnological industries. Through this Research Topic, the goal is to encourage the researchers to describe experimental datasets, novel technological interventions, and case studies to comprehend the concept of microbiome diagnostics and therapeutic interventions.

In this Research Topic, we would like to welcome manuscripts in the form of original research, review, case studies, and novel technological interventions primarily focusing on the exploration or application of human microbiome for diagnostic and therapeutic applications. The key focus areas are:

> Human microbiome based disease prognosis and diagnosis

> Microbial therapies (Additive, Subtractive, and Modulatory) for disease management

> Prebiotics, Postbiotics, Diet, Yoga, and Exercise derived microbiome modulation

> Treatment and prevention of human diseases with designer probiotics

> Fecal Microbiota transplantation to overcome illnesses and infections

> Technological and scientific innovations to comprehend the concept of microbiome diagnostics and interventions

Keywords: Microbiome Therapeutics, Microbiome diagnostics, Microbial Markers, Community Modeling, Microbial Therapy, Probiotics, Prebiotics, Fecal Microbiome Transplantation, Bacteriophage Therapy, Antimicrobial Therapy

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