Epithelial cells and innate immune cells (e.g., macrophages, dendritic cells, and innate lymphoid cells) have a central role in mediating the innate immune response in nasal mucosa; meanwhile, alteration of innate immunity consequently leading to the activation of downstream effector cells is crucial for the initiation and development of upper airway inflammation and diseases, such as allergic rhinitis and chronic rhinosinusitis.
Nasal epithelium has an essential role in maintaining the airway mucosal homeostasis. It is now recognized that the epithelium of the upper respiratory tract is not merely a physical barrier, but also plays important roles in the pathophysiology of upper airway pathology. Nasal epithelium shows a prominent innate immune function against detrimental agents, including bacteria, viruses, allergens, and air pollutants; meanwhile, the epithelium is considered to trigger immune response during the onset of upper airway inflammation; in addition, impairment of epithelial repair and abnormal epithelial remodeling are critical pathological changes in chronic nasal inflammatory diseases.
By utilizing new sequencing techniques, characterization of the nasal microbiome has changed our understanding of the development of chronic upper airway inflammatory diseases. Imbalance or dysbiosis in the upper airway microbiota has been highlighted as a possible pathogenic factor to trigger nasal inflammation. Beside descriptive studies about the diversity of microbiota, the association between microbiome patterns and specific phenotypes/endotypes of chronic nasal inflammation, as well as how microbiome impacts on mucosal immunity in the upper airway remains to be investigated.
In the current Research Topic, we aim to assemble a series of articles that investigate how the nasal epithelial cells and innate immune cells contribute to the mucosal inflammation and their responses to pathogens and environmental factors; and gather cutting-edge research in the field of nasal microbiome and its relationship with upper airway inflammation.
We welcome the submission of Review, Mini-Review, Original Research articles addressing the following subtopics, but not limited to:
• The role of epithelial barrier dysfunction in development of chronic nasal inflammation
• The role of innate immune cells in chronic nasal inflammation
• Host immune response of nasal epithelial cells against viruses, bacteria, allergens, and environmental pollutants
• Role of nasal microbiome in the upper airway inflammation
Epithelial cells and innate immune cells (e.g., macrophages, dendritic cells, and innate lymphoid cells) have a central role in mediating the innate immune response in nasal mucosa; meanwhile, alteration of innate immunity consequently leading to the activation of downstream effector cells is crucial for the initiation and development of upper airway inflammation and diseases, such as allergic rhinitis and chronic rhinosinusitis.
Nasal epithelium has an essential role in maintaining the airway mucosal homeostasis. It is now recognized that the epithelium of the upper respiratory tract is not merely a physical barrier, but also plays important roles in the pathophysiology of upper airway pathology. Nasal epithelium shows a prominent innate immune function against detrimental agents, including bacteria, viruses, allergens, and air pollutants; meanwhile, the epithelium is considered to trigger immune response during the onset of upper airway inflammation; in addition, impairment of epithelial repair and abnormal epithelial remodeling are critical pathological changes in chronic nasal inflammatory diseases.
By utilizing new sequencing techniques, characterization of the nasal microbiome has changed our understanding of the development of chronic upper airway inflammatory diseases. Imbalance or dysbiosis in the upper airway microbiota has been highlighted as a possible pathogenic factor to trigger nasal inflammation. Beside descriptive studies about the diversity of microbiota, the association between microbiome patterns and specific phenotypes/endotypes of chronic nasal inflammation, as well as how microbiome impacts on mucosal immunity in the upper airway remains to be investigated.
In the current Research Topic, we aim to assemble a series of articles that investigate how the nasal epithelial cells and innate immune cells contribute to the mucosal inflammation and their responses to pathogens and environmental factors; and gather cutting-edge research in the field of nasal microbiome and its relationship with upper airway inflammation.
We welcome the submission of Review, Mini-Review, Original Research articles addressing the following subtopics, but not limited to:
• The role of epithelial barrier dysfunction in development of chronic nasal inflammation
• The role of innate immune cells in chronic nasal inflammation
• Host immune response of nasal epithelial cells against viruses, bacteria, allergens, and environmental pollutants
• Role of nasal microbiome in the upper airway inflammation
