Human herpesviruses are ubiquitous pathogens causing a variety of diseases, from mild skin lesions to life-threatening encephalitis, from congenital disorders to neurodegenerative diseases, as well as various kinds of malignancies. The life cycle of herpesviruses consists of two phases, latent infection and lytic replication: herpesviruses establish life-long latent infection in the hosts and can switch to lytic replication under certain circumstances. At both phases, virus-host interactions, with feasible protein and RNA factors involved, are required for the process of infection, replication, and pathogenesis.
Elucidating the herpesvirus-host interaction network, particularly defining the pivotal roles of viral/host proteins and non-coding RNAs, will not only deepen our understanding of the basics of herpesvirus infection and pathogenesis but also provide great opportunities for the development of novel therapeutics.
In this Research Topic, we will incorporate novel findings in all aspects of herpesvirus-host interactions, focusing on the fundamental roles of viral/host proteins and non-coding RNAs during herpesvirus infection. We are also interested in original work on exploring proteomics dynamics and cross-talk of signaling pathways related to herpesvirus infection and pathogenesis.
We welcome submissions of the following article types: Original Research, Brief Research Report, Review, Mini Review, Editorial, Perspective, General Commentary, Hypothesis and Theory, Methods, and Opinion. Submissions are welcomed from, but not limited to, the following areas:
• Protein-protein, protein-RNA, or RNA-RNA interactions in herpesvirus infection
• Role of proteins and/or noncoding RNAs in the life cycle and pathogenesis of herpesviruses
• Proteomics study on herpesvirus infection and pathogenesis
• Cross-talk of different signaling pathways activated by herpesviruses
• Novel antivirals by targeting herpesvirus-host interactions.
Human herpesviruses are ubiquitous pathogens causing a variety of diseases, from mild skin lesions to life-threatening encephalitis, from congenital disorders to neurodegenerative diseases, as well as various kinds of malignancies. The life cycle of herpesviruses consists of two phases, latent infection and lytic replication: herpesviruses establish life-long latent infection in the hosts and can switch to lytic replication under certain circumstances. At both phases, virus-host interactions, with feasible protein and RNA factors involved, are required for the process of infection, replication, and pathogenesis.
Elucidating the herpesvirus-host interaction network, particularly defining the pivotal roles of viral/host proteins and non-coding RNAs, will not only deepen our understanding of the basics of herpesvirus infection and pathogenesis but also provide great opportunities for the development of novel therapeutics.
In this Research Topic, we will incorporate novel findings in all aspects of herpesvirus-host interactions, focusing on the fundamental roles of viral/host proteins and non-coding RNAs during herpesvirus infection. We are also interested in original work on exploring proteomics dynamics and cross-talk of signaling pathways related to herpesvirus infection and pathogenesis.
We welcome submissions of the following article types: Original Research, Brief Research Report, Review, Mini Review, Editorial, Perspective, General Commentary, Hypothesis and Theory, Methods, and Opinion. Submissions are welcomed from, but not limited to, the following areas:
• Protein-protein, protein-RNA, or RNA-RNA interactions in herpesvirus infection
• Role of proteins and/or noncoding RNAs in the life cycle and pathogenesis of herpesviruses
• Proteomics study on herpesvirus infection and pathogenesis
• Cross-talk of different signaling pathways activated by herpesviruses
• Novel antivirals by targeting herpesvirus-host interactions.