The liver plays a central role in metabolic homeostasis and is a major site for synthesis, metabolism, storage and redistribution of glucose and lipids. Metabolic processes in the liver include lipogenesis, fatty acid oxidation, gluconeogenesis, cholesterol biosynthesis and elimination, and lipoprotein transport. It is well known that glucose and lipid metabolism are precisely regulated in healthy individuals. However, disorders of hepatic glucose and lipid metabolism contribute to and result in several metabolic diseases including diabetes, insulin resistance, obesity, fatty liver disease, and atherosclerotic cardiovascular diseases, which are rising rapidly worldwide. Thus, understanding the underlying mechanisms that control hepatic lipid and glucose metabolism can provide potential targets and rationale basis for novel therapeutic strategies.
This Research Topic focuses on the molecular mechanisms of novel regulators or pathways relevant to hepatic glucose and lipid metabolism associated with metabolic diseases, and potential therapeutic applications through translational medicine.
We welcome contributions including Original Research, Review, Mini-review, Clinical Trial, and Perspective Articles covering, but not limited to the following subjects:
• Novel regulators or pathways in the liver that lead to glucose or lipid metabolic dysfunction.
• Crosstalk between liver and other metabolic tissues (i.e.: adipose tissues, skeletal muscle) which contribute to hepatic energy metabolism.
• Potential chemicals or medicines for intervention or management of metabolic diseases through regulation of hepatic glucose and lipid metabolism.
The liver plays a central role in metabolic homeostasis and is a major site for synthesis, metabolism, storage and redistribution of glucose and lipids. Metabolic processes in the liver include lipogenesis, fatty acid oxidation, gluconeogenesis, cholesterol biosynthesis and elimination, and lipoprotein transport. It is well known that glucose and lipid metabolism are precisely regulated in healthy individuals. However, disorders of hepatic glucose and lipid metabolism contribute to and result in several metabolic diseases including diabetes, insulin resistance, obesity, fatty liver disease, and atherosclerotic cardiovascular diseases, which are rising rapidly worldwide. Thus, understanding the underlying mechanisms that control hepatic lipid and glucose metabolism can provide potential targets and rationale basis for novel therapeutic strategies.
This Research Topic focuses on the molecular mechanisms of novel regulators or pathways relevant to hepatic glucose and lipid metabolism associated with metabolic diseases, and potential therapeutic applications through translational medicine.
We welcome contributions including Original Research, Review, Mini-review, Clinical Trial, and Perspective Articles covering, but not limited to the following subjects:
• Novel regulators or pathways in the liver that lead to glucose or lipid metabolic dysfunction.
• Crosstalk between liver and other metabolic tissues (i.e.: adipose tissues, skeletal muscle) which contribute to hepatic energy metabolism.
• Potential chemicals or medicines for intervention or management of metabolic diseases through regulation of hepatic glucose and lipid metabolism.