Bacteria control the adapting ability of communities through a common mechanism, namely the quorum sensing system (QSS), which regulates a number of specific functions, such as virulence, symbiosis, competence, conjugation, antibiotic production, motility, and biofilm formation.
The main steps of the QSS pathway include the biosynthesis, diffusion, accumulation of the auto-inducer, and the perception of the QSS signals through the receptor by itself or other bacteria. Quorum quenching refers to all processes involved in the disturbance of quorum system, such as inhibition of the QSS expression, inactivation of the QQS enzymes and blockage of the auto-inducer receptor. As a consequence, the disruption of QSS is a very promising target for finding novel anti-infective therapies and the study of the mechanism of quorum quenching has recently produced an extensive amount of data, which is disseminated among literature.
Some of the data allowed for the development of new drugs, for instance, new inhibitors of the pqs QSS were identified in the human pathogen Pseudomonas aeruginosa. The Food and Drug Administration approved the most active inhibitor, clofoctol, specifically inhibiting the expression of pqs-controlled virulence, such as pyocyanin production, swarming motility, biofilm formation, and expression of genes involved in siderophore production.
In this Research Topic, we will focus on:
• The advances in the signaling of quorum sensing system especially in Pseudomonas aeruginosa and Staphylococcus aureus
• The molecular mechanisms that trigger quorum quenching
• The antibacterial therapeutic targets and strategies which might be developed
• The pharmaceutical properties of the potential therapeutic drugs developed with this approach.
We welcome Reviews or Research Articles related to this mission with the aim of gathering the most recent findings on this promising field for developing antibacterial drugs, thereby further the development of clinical applications and novel drugs.
Bacteria control the adapting ability of communities through a common mechanism, namely the quorum sensing system (QSS), which regulates a number of specific functions, such as virulence, symbiosis, competence, conjugation, antibiotic production, motility, and biofilm formation.
The main steps of the QSS pathway include the biosynthesis, diffusion, accumulation of the auto-inducer, and the perception of the QSS signals through the receptor by itself or other bacteria. Quorum quenching refers to all processes involved in the disturbance of quorum system, such as inhibition of the QSS expression, inactivation of the QQS enzymes and blockage of the auto-inducer receptor. As a consequence, the disruption of QSS is a very promising target for finding novel anti-infective therapies and the study of the mechanism of quorum quenching has recently produced an extensive amount of data, which is disseminated among literature.
Some of the data allowed for the development of new drugs, for instance, new inhibitors of the pqs QSS were identified in the human pathogen Pseudomonas aeruginosa. The Food and Drug Administration approved the most active inhibitor, clofoctol, specifically inhibiting the expression of pqs-controlled virulence, such as pyocyanin production, swarming motility, biofilm formation, and expression of genes involved in siderophore production.
In this Research Topic, we will focus on:
• The advances in the signaling of quorum sensing system especially in Pseudomonas aeruginosa and Staphylococcus aureus
• The molecular mechanisms that trigger quorum quenching
• The antibacterial therapeutic targets and strategies which might be developed
• The pharmaceutical properties of the potential therapeutic drugs developed with this approach.
We welcome Reviews or Research Articles related to this mission with the aim of gathering the most recent findings on this promising field for developing antibacterial drugs, thereby further the development of clinical applications and novel drugs.
