Cardiometabolic diseases related to obesity, such as insulin resistance, diabetes and fatty liver disease, are major risk factors for the development of cardiovascular disease. Recent evidence suggests that hormones normally associated with coordinating metabolism play significant roles in modulating inflammation. This is important because these metabolic hormones may become chronically dysregulated in diseases linked to obesity and may therefore impact progression of cardiovascular disease through previously unrecognised mechanisms, including modulating inflammatory responses.
Many hormones and hormone-like molecules are involved in the coordination of metabolism, and immune cells express receptors for these metabolic regulators. While hormones are classically defined as the signalling molecules produced by the specialised glands of the endocrine system, for the scope of this research topic we are also including signalling molecules secreted by any tissue used to coordinate systemic metabolism - for example adipokines, histamine, cytokines, and chemokines. This research topic aims to highlight to the cardiometabolic community the novel roles of metabolic mediators in inflammation and shed light on mechanisms that may be targeted for future therapeutic strategies.
Specific themes we would like contributors to address include, but are not limited to:
1) The effects of metabolic hormones on inflammatory cells.
2) The effects of metabolic hormones on global inflammatory responses.
3) Regulation and dysregulation of metabolic hormones and inflammation in cardiometabolic disease.
4) Novel models for investigating the inflammatory effects of metabolic hormones.
5) Studies investigating the effects of metabolic hormones on specialized pro-resolving mediators.
Cardiometabolic diseases related to obesity, such as insulin resistance, diabetes and fatty liver disease, are major risk factors for the development of cardiovascular disease. Recent evidence suggests that hormones normally associated with coordinating metabolism play significant roles in modulating inflammation. This is important because these metabolic hormones may become chronically dysregulated in diseases linked to obesity and may therefore impact progression of cardiovascular disease through previously unrecognised mechanisms, including modulating inflammatory responses.
Many hormones and hormone-like molecules are involved in the coordination of metabolism, and immune cells express receptors for these metabolic regulators. While hormones are classically defined as the signalling molecules produced by the specialised glands of the endocrine system, for the scope of this research topic we are also including signalling molecules secreted by any tissue used to coordinate systemic metabolism - for example adipokines, histamine, cytokines, and chemokines. This research topic aims to highlight to the cardiometabolic community the novel roles of metabolic mediators in inflammation and shed light on mechanisms that may be targeted for future therapeutic strategies.
Specific themes we would like contributors to address include, but are not limited to:
1) The effects of metabolic hormones on inflammatory cells.
2) The effects of metabolic hormones on global inflammatory responses.
3) Regulation and dysregulation of metabolic hormones and inflammation in cardiometabolic disease.
4) Novel models for investigating the inflammatory effects of metabolic hormones.
5) Studies investigating the effects of metabolic hormones on specialized pro-resolving mediators.
