Inflammatory diseases of the nervous system are common causes of neurological dysfunction in domestic animals. These diseases can be caused by a wide variety of etiologies, some of which are important or emerging zoonoses. These conditions have been clinically recognized for many years, and there have been advancements in the diagnosis and treatment of infectious and, to a lesser extent, immune-mediated meningoencephalitides. However, the etiopathogenesis of many of these diseases, and particularly how they impact local and systemic neural-immunologic homeostasis and interactions, remains poorly characterized. This mechanistic knowledge gap presents a significant obstacle to the development of improved diagnostic methods and evidence-based, standard-of-care treatments.
The clinical management of animals with neuroinflammatory diseases is a complex and chronic process which may include neuroimaging and cerebrospinal fluid examinations, extensive serological or molecular profiling for infectious etiologies, protracted multidrug therapeutic regimens, and frequent follow-up care and therapeutic monitoring. There is a relative paucity of literature available to veterinarians that provides best practice guidelines for many of these management processes. This Research Topic is intended to showcase the latest research and review articles on infectious and immune-mediated neuroinflammatory diseases in order to expand our knowledge and advance the clinical care of domestic animals with these diseases, as well as highlight implications these disorders may have on human health.
This Research Topic invites contributions relating, but not limited, to:
• Antemortem diagnosis of neuroinflammatory diseases
• Clinical decision making and therapeutic monitoring in neuroinflammatory diseases
• Treatment protocols or meta-analyses for neuroinflammatory diseases
• Immunopathology and mechanisms of disease
• Liquid biopsy/biomarkers of neuroinflammatory diseases
• “-omics” of neuroinflammatory diseases
Inflammatory diseases of the nervous system are common causes of neurological dysfunction in domestic animals. These diseases can be caused by a wide variety of etiologies, some of which are important or emerging zoonoses. These conditions have been clinically recognized for many years, and there have been advancements in the diagnosis and treatment of infectious and, to a lesser extent, immune-mediated meningoencephalitides. However, the etiopathogenesis of many of these diseases, and particularly how they impact local and systemic neural-immunologic homeostasis and interactions, remains poorly characterized. This mechanistic knowledge gap presents a significant obstacle to the development of improved diagnostic methods and evidence-based, standard-of-care treatments.
The clinical management of animals with neuroinflammatory diseases is a complex and chronic process which may include neuroimaging and cerebrospinal fluid examinations, extensive serological or molecular profiling for infectious etiologies, protracted multidrug therapeutic regimens, and frequent follow-up care and therapeutic monitoring. There is a relative paucity of literature available to veterinarians that provides best practice guidelines for many of these management processes. This Research Topic is intended to showcase the latest research and review articles on infectious and immune-mediated neuroinflammatory diseases in order to expand our knowledge and advance the clinical care of domestic animals with these diseases, as well as highlight implications these disorders may have on human health.
This Research Topic invites contributions relating, but not limited, to:
• Antemortem diagnosis of neuroinflammatory diseases
• Clinical decision making and therapeutic monitoring in neuroinflammatory diseases
• Treatment protocols or meta-analyses for neuroinflammatory diseases
• Immunopathology and mechanisms of disease
• Liquid biopsy/biomarkers of neuroinflammatory diseases
• “-omics” of neuroinflammatory diseases
