About this Research Topic
This Research Topic is part of the Model Organisms in Aging Research series. Other titles in this series are:
• Model Organisms in Aging Research:Caenorhabditis elegans
• Model Organisms in Aging Research: Rodent Models
Background
The discovery of longevity pathways in invertebrate model organisms has been pivotal for the explosion of research in the aging field. Model organisms are amenable to both genetic manipulation and environmental interventions that extend lifespan, slow down the appearance of aging biomarkers and rejuvenate tissues. The simplicity of invertebrates allows the development of concepts and technologies that can then be applied to more complex organisms, including humans.
Goals
Successful strategies developed in Drosophila melanogaster have been useful in studying diverse aspects of aging research, such as the impact of genetics. This has led to key insights into the non-linear relationship between metabolic, immune, genetic, behavioral and aging processes. The goal of this Research Topic is to publish research in any of these areas aided by research with the Drosophila melanogaster.
Scope and information for Authors
Manuscripts submitted to this Research Topic should include or consider the role of Drosophila melanogaster for aging research. The scope of this Research Topic covers, but is not limited to, the following themes and questions:
• The genetics of aging; insights from Drosophila melanogaster
• Using flies to test anti-aging interventions (this could include diet restriction as one subtopic and drugs as another)
• The impact of Drosophila melanogaster research on the aging immune system
• The aging fly: mitochondrial and metabolic insights
• Insights from flies into neurological and behavioral aging
• The strengths and limitations of using Drosophila melanogaster as a model organism for aging research
• Model Organisms in Aging Research:Caenorhabditis elegans
• Model Organisms in Aging Research: Rodent Models
Background
The discovery of longevity pathways in invertebrate model organisms has been pivotal for the explosion of research in the aging field. Model organisms are amenable to both genetic manipulation and environmental interventions that extend lifespan, slow down the appearance of aging biomarkers and rejuvenate tissues. The simplicity of invertebrates allows the development of concepts and technologies that can then be applied to more complex organisms, including humans.
Goals
Successful strategies developed in Drosophila melanogaster have been useful in studying diverse aspects of aging research, such as the impact of genetics. This has led to key insights into the non-linear relationship between metabolic, immune, genetic, behavioral and aging processes. The goal of this Research Topic is to publish research in any of these areas aided by research with the Drosophila melanogaster.
Scope and information for Authors
Manuscripts submitted to this Research Topic should include or consider the role of Drosophila melanogaster for aging research. The scope of this Research Topic covers, but is not limited to, the following themes and questions:
• The genetics of aging; insights from Drosophila melanogaster
• Using flies to test anti-aging interventions (this could include diet restriction as one subtopic and drugs as another)
• The impact of Drosophila melanogaster research on the aging immune system
• The aging fly: mitochondrial and metabolic insights
• Insights from flies into neurological and behavioral aging
• The strengths and limitations of using Drosophila melanogaster as a model organism for aging research
Keywords: Drosophila melanogaster, Aging Research, Model Organisms, Fruit Fly, Genetics, Aging Immunity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
