About this Research Topic
Bioactive sphingolipids, including sphingosine, ceramide, sphingosine-1-phosphate, ceramide-2-phosphate, are long known as the critical regulator of physiological and pathophysiological functions. These bioactive lipids act as a secondary messenger and target a variety of intracellular proteins, enzymes, and extracellular receptors. Acting on these targets eventually results in the regulation of diverse cellular activities that are critical for maintaining homeostasis. However, dysregulation of sphingolipids and enzymes required for their genesis is generally observed in diseases and disorders. In this context, careful manipulation of the sphingolipid pathways, using enzymes inhibitors or synthetic analogs can be suggested for achieving homeostasis. Therefore, targeting sphingolipid metabolism in diseases and disorders may provide therapeutic benefits. Moreover, it has been recently observed a role of sphingolipids as target in controlling infectious diseases.
Despite the tremendous amount of research done in the field of sphingolipidomic, our current understanding of studying the underlying mechanism is still limited as these bioactive lipids are interconvertible. In addition, due to the different isotypes of extracellular receptors of sphingolipids, it is difficult to understand the role of the exact receptor subtype on the activation or deactivation of sphingolipid signaling via the receptor. Our main goal will be to decipher the role of sphingolipids and the enzymes necessary for their metabolism in the regulation of the course of diseases, disorders and in controlling infectious diseases. In addition, we will be focusing on how we can artificially manipulate the sphingolipid signaling in diseases state and what will be the outcome.
In this Research Topic, we aim at collecting articles about recent and novel findings in the role of sphingolipid in the control of infectious diseases and in the regulation of disease and disorders. We welcome the submission of Original Research, Review, Mini Review, Perspective, and Opinion Articles on, but not limited to, the following topics:
• The role of sphingolipids in mediating pathogen-host cell interactions
• The role of sphingolipids as targets/effectors in infectious diseases
• The role of sphingolipids in disease and disorders signaling
• Therapeutic uses of sphingolipids
• Advance in the artificial manipulate of sphingolipid signaling in diseases and disorders.
Despite the tremendous amount of research done in the field of sphingolipidomic, our current understanding of studying the underlying mechanism is still limited as these bioactive lipids are interconvertible. In addition, due to the different isotypes of extracellular receptors of sphingolipids, it is difficult to understand the role of the exact receptor subtype on the activation or deactivation of sphingolipid signaling via the receptor. Our main goal will be to decipher the role of sphingolipids and the enzymes necessary for their metabolism in the regulation of the course of diseases, disorders and in controlling infectious diseases. In addition, we will be focusing on how we can artificially manipulate the sphingolipid signaling in diseases state and what will be the outcome.
In this Research Topic, we aim at collecting articles about recent and novel findings in the role of sphingolipid in the control of infectious diseases and in the regulation of disease and disorders. We welcome the submission of Original Research, Review, Mini Review, Perspective, and Opinion Articles on, but not limited to, the following topics:
• The role of sphingolipids in mediating pathogen-host cell interactions
• The role of sphingolipids as targets/effectors in infectious diseases
• The role of sphingolipids in disease and disorders signaling
• Therapeutic uses of sphingolipids
• Advance in the artificial manipulate of sphingolipid signaling in diseases and disorders.
Keywords: Sphingolipids, sphingosine-1-phosphate, ceramide-1-phosphate, sphingosine kinase, infectious diseases, cancer, neurological disorder.
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