Biomarkers of Perioperative Stroke in Older Patients

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Department of Anesthesiology, Affiliated Beijing Friendship Hospital, Capital Medical University

Southwest Hospital, Army Medical University

Zhejiang University

Department of Neurology, Second Hospital of Shanxi Medical University

Third Affiliated Hospital of Sun Yat-sen University

Loma Linda University

Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Cancer Hospital, Chongqing University

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Perioperative stroke is a complication that can be caused by surgery or anaesthesia and has a negative influence on patients’ recovery as well as higher mortality than patients without perioperative stroke. Age has been identified as a risk factor for perioperative stroke. As the world population ages, so will the average age of surgical patients. As a result, the incidence of perioperative stroke is anticipated to rise in the future. Despite advances in surgical techniques and perioperative care, the incidence of perioperative stroke has remained unchanged. This might be due to the lack of sensitivity and accuracy of perioperative stroke biomarkers during clinical treatments. As a result, identifying biomarkers for perioperative stroke, particularly in the elderly population, is crucial.

In this Research Topic, we would like to employ genomics, proteomics, transcriptomics, and brain imaging to identify biomarkers that can be useful for the diagnosis and prognosis of perioperative stroke in elderly patients. We welcome authors to contribute original research articles, review articles and perspectives/opinions.

Potential sub-topics include, but are not limited to:
-Molecular and cellular biomarkers for perioperative stroke diagnosis and prognosis in elderly patients
-Immunohistochemical histopathologic biomarkers, imaging biomarkers, or Serum cell-free DNA as a biomarker for perioperative stroke in elderly patients
-Classification of perioperative stroke subtypes by biomarkers
-Technological progress in biomarker discovery in perioperative stroke

Perioperative stroke is a complication that can be caused by surgery or anaesthesia and has a negative influence on patients’ recovery as well as higher mortality than patients without perioperative stroke. Age has been identified as a risk factor for perioperative stroke. As the world population ages, so will the average age of surgical patients. As a result, the incidence of perioperative stroke is anticipated to rise in the future. Despite advances in surgical techniques and perioperative care, the incidence of perioperative stroke has remained unchanged. This might be due to the lack of sensitivity and accuracy of perioperative stroke biomarkers during clinical treatments. As a result, identifying biomarkers for perioperative stroke, particularly in the elderly population, is crucial.

In this Research Topic, we would like to employ genomics, proteomics, transcriptomics, and brain imaging to identify biomarkers that can be useful for the diagnosis and prognosis of perioperative stroke in elderly patients. We welcome authors to contribute original research articles, review articles and perspectives/opinions.

Potential sub-topics include, but are not limited to:
-Molecular and cellular biomarkers for perioperative stroke diagnosis and prognosis in elderly patients
-Immunohistochemical histopathologic biomarkers, imaging biomarkers, or Serum cell-free DNA as a biomarker for perioperative stroke in elderly patients
-Classification of perioperative stroke subtypes by biomarkers
-Technological progress in biomarker discovery in perioperative stroke

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Editors

Department of Anesthesiology, Affiliated Beijing Friendship Hospital, Capital Medical University

Southwest Hospital, Army Medical University

Zhejiang University

Department of Neurology, Second Hospital of Shanxi Medical University

Third Affiliated Hospital of Sun Yat-sen University

Loma Linda University

Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Cancer Hospital, Chongqing University

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Frontiers in Aging Neuroscience

Neuroinflammation and Neuropathy, Alzheimer's Disease and Related Dementias, Neurocognitive Aging and Behavior, Cellular and Molecular Mechanisms of Brain-aging, Parkinson’s Disease and Aging-related Movement Disorders, Aging Neuroscience Archive

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