Redox Regulation and Signaling in Neurodegenerative Diseases

  • 6,940

    Total Downloads

  • 23k

    Total Views and Downloads

Submit your idea

Select the journal/section where you want your idea to be submitted:

Submit your manuscript summarySubmit your manuscript

About this Research Topic

Submission closed

Background

The physiological production of reactive oxygen, nitrogen and sulfur species is necessary to maintain correct intra- and intercellular signaling in any living tissue. These reactive species are essential for the regulated performance of cellular functions. In fact, oxidative eustress is key for the maintenance of cell morphology, differentiation, proliferation and cell death, among other functions. Changes in the production of different reactive species and alterations in the regulation of different redox related enzymes can lead to oxidative distress, causing major cellular changes that are closely connected to the onset and progression of neurodegenerative pathologies. The identification of affected biochemical pathways related to redox regulation in different brain areas has shed light on the origin of neurodegeneration in the central nervous system. There is increasing evidence suggesting that redox changes occur in the early stages of neurodegenerative diseases such as Amyotrophic lateral sclerosis, Alzheimer disease, Huntington disease and Parkinson´s disease. However, the brain areas affected by these pathologies are different and the pathophysiological characteristics they display are distinct from one another.

Current research in the field of neurodegenerative diseases is throwing light on the nature of the molecular changes that occur before the appearance of symptoms and that ultimately lead to cellular changes, neuronal loss and histological alterations. Some of these molecular modifications are linked to redox signaling and thus, redox regulation of different cellular functions. Our current aim is to elucidate in detail how redox active molecules and proteins, as well as redox-regulated circuits are affected in different neurodegenerative diseases. This will allow us, not only to understand the nature of these pathologies and the redox link that unites them, but also to describe, which events may be targets for new and innovative therapeutic strategies that could be applied to prevent and palliate the symptoms caused by these pathologies.

To this day, the causes that give rise to the hallmarks and symptoms of many neurodegenerative pathologies remain elusive. Therefore, we are particularly interested in original articles focused on alterations of redox-active molecules and/or redox-regulated cellular pathways, mainly in the early stages of neurodegenerative diseases. We also welcome the submission of clinical studies demonstrating changes in the levels of redox related molecules and altered redox states in different stages of neurodegenerative diseases. It is our aim to increase the knowledge related to the biochemical changes linked to redox homeostasis that give rise to neurodegeneration. Thus, review articles discussing the current state of the art are also welcome. This collection will allow us to better comprehend the nature of these pathologies and find new and innovative therapeutic targets to counter them in the future.

Keywords: Neurodegeneration, Central nervous system, Neurons, Glia, Redox regulation, Thiol switches, Oxidative distress

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and they fall under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

      In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

     

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

     

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

     

Impact

  • 23kTopic views
  • 16kArticle views
  • 6,940Article downloads
View impact