About this Research Topic
Dysregulated PTMs, which may be caused by many reasons, have been linked to the onset and progression of many of these age-related neurodegenerative diseases. Therefore, it is crucial to gain a deep understanding of the molecular regulatory mechanisms of posttranslational modifications, the consequences of the dysregulation of posttranslational modifications at molecular, cellular and organismal levels, and the extent to which these modifications are reversible. The advancement of modern molecular biology, biochemistry, neurobiology, genetic and epigenetic has provided a great opportunity for us to investigate the role of PTMs in age-related neurodegenerative diseases. These researches will also help in the development of new preventative and therapeutic approaches for age-related neurodegenerative diseases.
This Research Topic welcomes all original articles, reviews and reports related, but not limited to, the following sub-topics:
- The genetic and environmental factors that regulate PTMs in age-related neurodegenerative diseases
- The key mechanism underlying the activation and regulation of PTMs in age-related neurodegenerative diseases
- Dysregulated PTMs as the base of protein misfolding in age-related neurodegenerative diseases
- Targeting PTMs as a therapeutic strategy for age-related neurodegenerative diseases
- The emerging role of transnitrosylation in age-related neurodegenerative diseases
- The involvement of abnormal protein posttranslational modification networks in the pathogenesis of age-related neurodegenerative diseases
Keywords: Neurodegenerative Diseases, Post-translational Modifications, Phosphorylation, SUMOylation, Ubiquitination, Acetylation, Nitrosylation, Aging
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