The Genetics of Head and Neck Squamous Cell Carcinoma

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Xiamen Haicang Hospital

National Institute of Dental and Craniofacial Research (NIH)

Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University

Fujian Medical University Union Hospital

Guilin Medical University

Second Affiliated Hospital of Nanchang University

Jiujiang University

Howard University

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The majority of head and neck malignancies arise from the mucosal epithelium of the oral cavity, pharynx, and larynx and are collectively referred to as "head and neck squamous cell carcinoma" (HNSCC). It is the sixth most common cancer, with approximately 650,000 new cases diagnosed annually worldwide. Despite major advances in our understanding of the underlying molecular mechanisms, diagnostic and therapeutic approaches, approximately 400,000 people die from this disease each year.

The advent of high-throughput genomic technologies has contributed to a better understanding of HNSCC, particularly in regards to developing precision medicine approaches aimed towards refined diagnosis and selection of targeted therapies. However, the molecular etiologies of HNSCC are not fully understood.

This Research Topic focuses on the following aspects: 1) exploring the genomics of HNSCC to uncover genomic causes at the molecular level, such as specific mutations or structural genome variations and abnormal expression of genes related to oncogenetic processes; 2) delineating of genomic markers with diagnostic relevance, especially with focus on early HNSCC detection; 3) identifying precise therapeutic targets for future immunotherapy, gene therapy, and chemotherapy.

We welcome submissions of original research papers, reviews, and methods, including (but not limited to) the following areas:

-Germline and somatic genomic variations in HNSCC
-Molecular profiling of the HNSCC tumor microenvironment
-Biomarkers for immunotherapy and other targeted therapeutic approaches for HNSCC
-Pharmacogenetic considerations for optimizing HNSCC therapy
-Genetic risk factors for HNSCC

The majority of head and neck malignancies arise from the mucosal epithelium of the oral cavity, pharynx, and larynx and are collectively referred to as "head and neck squamous cell carcinoma" (HNSCC). It is the sixth most common cancer, with approximately 650,000 new cases diagnosed annually worldwide. Despite major advances in our understanding of the underlying molecular mechanisms, diagnostic and therapeutic approaches, approximately 400,000 people die from this disease each year.

The advent of high-throughput genomic technologies has contributed to a better understanding of HNSCC, particularly in regards to developing precision medicine approaches aimed towards refined diagnosis and selection of targeted therapies. However, the molecular etiologies of HNSCC are not fully understood.

This Research Topic focuses on the following aspects: 1) exploring the genomics of HNSCC to uncover genomic causes at the molecular level, such as specific mutations or structural genome variations and abnormal expression of genes related to oncogenetic processes; 2) delineating of genomic markers with diagnostic relevance, especially with focus on early HNSCC detection; 3) identifying precise therapeutic targets for future immunotherapy, gene therapy, and chemotherapy.

We welcome submissions of original research papers, reviews, and methods, including (but not limited to) the following areas:

-Germline and somatic genomic variations in HNSCC
-Molecular profiling of the HNSCC tumor microenvironment
-Biomarkers for immunotherapy and other targeted therapeutic approaches for HNSCC
-Pharmacogenetic considerations for optimizing HNSCC therapy
-Genetic risk factors for HNSCC

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Editors

Xiamen Haicang Hospital

National Institute of Dental and Craniofacial Research (NIH)

Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University

Fujian Medical University Union Hospital

Guilin Medical University

Second Affiliated Hospital of Nanchang University

Jiujiang University

Howard University

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Frontiers in Genetics

Cancer Genetics and Oncogenomics

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