About this Research Topic
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide. According to the World Health Organization GLOBOCAN database, CRC is the third most commonly diagnosed cancer in males and the second in females. Age, hereditary factors, lifestyle determinants including sedentary lifestyle, obesity, red meat consumption, smoking, and alcohol consumption, and long-term bowel inflammation have been associated with CRC.
CRC incidence and mortality rates vary around the world with the highest incidence rates in Europe, Australia and New Zealand, and North America, and the lowest rates are found in Africa and South-Central Asia. The CRC incidence rate has drastically increased in recent decades in some countries such as Korea, Japan, and China. These geographical differences can be attributed to dietary differences, environmental exposure, and genetic differences.
Due to the success of personalized therapy and screening programs, mortality from this disease has reduced in recent years. However, evidence has shown that early-onset (<50 years old) CRC has been increasing worldwide while incidence is decreasing in older age groups. The rising incidence of early-onset CRC has prompted the consideration of lowering the age of first screening. Further research is needed to strengthen the understanding of other environmental and genetic risk factors, and the molecular evolution of the disease.
We welcome papers on the following topics:
- Incidence, mortality and survival for CRC
- Etiology of CRC
- Nonmodifiable risk factors for CRC including age, ethnicity, sex, genetics, inflammatory bowel disease etc.
- Modifiable risk factors for CRC including diet, smoking, alcohol consumption, physical activity etc.
- Prevention strategies for CRC.
- Screening for CRC
- Risk of second primary malignancies in CRC patients
Please note, manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases, eg. SEER, which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in this section
CRC incidence and mortality rates vary around the world with the highest incidence rates in Europe, Australia and New Zealand, and North America, and the lowest rates are found in Africa and South-Central Asia. The CRC incidence rate has drastically increased in recent decades in some countries such as Korea, Japan, and China. These geographical differences can be attributed to dietary differences, environmental exposure, and genetic differences.
Due to the success of personalized therapy and screening programs, mortality from this disease has reduced in recent years. However, evidence has shown that early-onset (<50 years old) CRC has been increasing worldwide while incidence is decreasing in older age groups. The rising incidence of early-onset CRC has prompted the consideration of lowering the age of first screening. Further research is needed to strengthen the understanding of other environmental and genetic risk factors, and the molecular evolution of the disease.
We welcome papers on the following topics:
- Incidence, mortality and survival for CRC
- Etiology of CRC
- Nonmodifiable risk factors for CRC including age, ethnicity, sex, genetics, inflammatory bowel disease etc.
- Modifiable risk factors for CRC including diet, smoking, alcohol consumption, physical activity etc.
- Prevention strategies for CRC.
- Screening for CRC
- Risk of second primary malignancies in CRC patients
Please note, manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases, eg. SEER, which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in this section
Keywords: colorectal cancer, incidence, mortality, risk, genetic
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
