Respiratory diseases represent significant causes of hospitalization and important causes of death in children worldwide. Pre-emptive interventions are usually challenging since decision-makers are hampered by the scarcity of information on the mechanism of disease and its relationship with clinical outcomes. Translational research pursues to generate a linkage between lab results and direct benefits to human health. In recent decades, this rapidly expanding field has become a focus of interest from both funding agencies and research groups, pushed as a main line to improve health care practice. Therefore, there is a critical necessity to start building capacity to support and promote basic science and translational research to strengthen the existing evidence base for the management of respiratory illnesses in children.
In pediatric respiratory diseases, translational research can provide a more accurate understanding of pathophysiological mechanisms of illnesses, allowing to design new diagnoses and treatment strategies quicker than by basic or clinical approaches alone. Indeed, several respiratory diseases have clinical presentations that are far from uniform. For instance, bronchiolitis presents overlapping symptoms of varying intensity and these variations can randomly be produced by more than a dozen of viruses with different clinical phenotypes. Similarly, the syndrome we refer to as asthma can be a consequence of a wide range of different underlying mechanisms of disease.
In this Research Topic, we are interested in studies of prevalent pediatric respiratory diseases based on translational research findings that can move basic science discoveries into clinical practice more efficiently. Submissions may include original research articles as well as review articles in areas related to pediatric respiratory diseases, addressing the following topics:
- Asthma
- Pneumonia
- Bronchiolitis
- Bronchopulmonary dysplasia
- Cystic fibrosis
- Wheezing
- Sleep-disordered breathing including central and obstructive apnea
- Respiratory failure
- Chronic Obstructive Pulmonary Disease
- Pleural Effusion
- Bronchiectasis
- Respiratory viruses
- Lower respiratory tract infection.
Respiratory diseases represent significant causes of hospitalization and important causes of death in children worldwide. Pre-emptive interventions are usually challenging since decision-makers are hampered by the scarcity of information on the mechanism of disease and its relationship with clinical outcomes. Translational research pursues to generate a linkage between lab results and direct benefits to human health. In recent decades, this rapidly expanding field has become a focus of interest from both funding agencies and research groups, pushed as a main line to improve health care practice. Therefore, there is a critical necessity to start building capacity to support and promote basic science and translational research to strengthen the existing evidence base for the management of respiratory illnesses in children.
In pediatric respiratory diseases, translational research can provide a more accurate understanding of pathophysiological mechanisms of illnesses, allowing to design new diagnoses and treatment strategies quicker than by basic or clinical approaches alone. Indeed, several respiratory diseases have clinical presentations that are far from uniform. For instance, bronchiolitis presents overlapping symptoms of varying intensity and these variations can randomly be produced by more than a dozen of viruses with different clinical phenotypes. Similarly, the syndrome we refer to as asthma can be a consequence of a wide range of different underlying mechanisms of disease.
In this Research Topic, we are interested in studies of prevalent pediatric respiratory diseases based on translational research findings that can move basic science discoveries into clinical practice more efficiently. Submissions may include original research articles as well as review articles in areas related to pediatric respiratory diseases, addressing the following topics:
- Asthma
- Pneumonia
- Bronchiolitis
- Bronchopulmonary dysplasia
- Cystic fibrosis
- Wheezing
- Sleep-disordered breathing including central and obstructive apnea
- Respiratory failure
- Chronic Obstructive Pulmonary Disease
- Pleural Effusion
- Bronchiectasis
- Respiratory viruses
- Lower respiratory tract infection.
