Bioactive Agents for Functionalization of Biomaterials for Precise Tissue Engineering

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Editorial

31 January 2023

Editorial: Bioactive agents for functionalization of biomaterials for precise tissue engineering

Gang Wu

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Hangzhou Medical College

Jinan University

Jenneke Klein-Nulend

Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam Movement Sciences

Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University

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Tissue engineering is a multidisciplinary technology to improve or replace biological tissues. Biomaterial scaffolds are an indispensable element in tissue engineering. A large variety of biomaterial scaffolds are widely adopted to facilitate the precise engineering of various tissues.

The biomaterials scaffolds can be naturally derived and synthesized organic, inorganic, metallic, and hybrid materials. To facilitate precise tissue engineering, biomaterials can be further bio-functionalized by various bioactive agents. Bioactive agents can be naturally derived or synthetic cytokines, growth factors, extracellular vesicles, small-molecules, and peptides with one or multiple functions, such as osteoinduction, osteoconduction, anti-inflammation, anti-cancer, and anti-osteoclast. The methods to integrate bioactive agents into implants include internal incorporation, electrostatic deposition, surface modification, and entrapment.

This Research Topic focuses on both basic and applied research on the bio-functionalized biomaterial scaffolds with various bioactive agents to promote the regeneration of tissues and restore the functions of tissues and/or organs. The topic welcomes, but is not limited to e.g. Original Research, Reviews, Mini Reviews, the following research areas:

1) Design, development, and evaluation of novel bioactive agents for tissue engineering

2) New application of bioactive agents to functionalize biomaterial scaffolds

3) Development and characterization of bio-functionalization techniques for biomaterial scaffolds

4) Application of bioactive agents to promote cells-scaffold interactions for tissue regeneration

5) Advanced systems based on functional biomaterials and stem cells

Tissue engineering is a multidisciplinary technology to improve or replace biological tissues. Biomaterial scaffolds are an indispensable element in tissue engineering. A large variety of biomaterial scaffolds are widely adopted to facilitate the precise engineering of various tissues.

The biomaterials scaffolds can be naturally derived and synthesized organic, inorganic, metallic, and hybrid materials. To facilitate precise tissue engineering, biomaterials can be further bio-functionalized by various bioactive agents. Bioactive agents can be naturally derived or synthetic cytokines, growth factors, extracellular vesicles, small-molecules, and peptides with one or multiple functions, such as osteoinduction, osteoconduction, anti-inflammation, anti-cancer, and anti-osteoclast. The methods to integrate bioactive agents into implants include internal incorporation, electrostatic deposition, surface modification, and entrapment.

This Research Topic focuses on both basic and applied research on the bio-functionalized biomaterial scaffolds with various bioactive agents to promote the regeneration of tissues and restore the functions of tissues and/or organs. The topic welcomes, but is not limited to e.g. Original Research, Reviews, Mini Reviews, the following research areas:

1) Design, development, and evaluation of novel bioactive agents for tissue engineering

2) New application of bioactive agents to functionalize biomaterial scaffolds

3) Development and characterization of bio-functionalization techniques for biomaterial scaffolds

4) Application of bioactive agents to promote cells-scaffold interactions for tissue regeneration

5) Advanced systems based on functional biomaterials and stem cells

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Editors

Hangzhou Medical College

Jinan University

Jenneke Klein-Nulend

Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam Movement Sciences

Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University

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Frontiers in Bioengineering and Biotechnology

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Frontiers in Materials

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Frontiers in Molecular Biosciences

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