Innate Trained or Memory Response in Transplantation

During organ transplantation, how the host recognizes "self" and "non-self" is the basis of immune response. For a long time, the acquired immunity has been believed to recognize "self" and "non-self". Clinically, through targeting acquired immunity, acute rejection is greatly suppressed and the short-term survival rate of organ transplants is improved. However, chronic rejection still exists, and the long-term survival rate of organ transplants is still suboptimal. Recent advances have highlighted the critical role of the innate immune system in initiating the immune response against the transplanted allograft and mediating chronic rejection. Therefore, by understanding the role of innate immune cells in chronic rejection could potentially improve the clinical applications.

Innate immune cells and innate trained/memory immunity provides new opportunities to rewire chronic rejection, but which and how innate cells initiate and maintain chronic rejection remains incompletely defined. Therefore, understanding the innate trained/memory immunity may provide opportunities to rewire the immune network that drives the chronic rejection. The goal of this Research Topic is to explore the potential precise mechanisms towards the innate immune cell types in chronic rejection.

We welcome submissions of Original Research and Review on the sub-topics below:
• Identification of innate cell population in chronic rejection
• Identification of innate receptor in chronic rejection
• Mechanisms of innate trained/memory immunity in chronic rejection
• The factors triggering innate trained/memory immunity
• Immune metabolic pathways in innate trained/memory immunity